Results 21 to 30 of about 38,690 (242)
Heliyon, 2021 Gain-of-function mutations in voltage-gated sodium channels (NaV1.7, NaV1.8, and NaV1.9) are known causes of inherited pain disorders. Identification and functional assessment of new NaV1.7 mutations could help elucidate the phenotypic spectrum of NaV1.7
Kiichi Takahashi +9 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2017 During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and firing of CA3 pyramidal cells followed by afterhyperpolarization ...
Ilgam Khalilov +7 more
doaj +1 more source
Scanning ion conductance microscopy: A nanotechnology for biological studies in live cells
Frontiers in Physiology, 2013 Scanning ion conductance microscope (SICM), which enables high-resolution imaging of cell surface topography, has been developed for over two decades. However, only recently, a unique scanning mode is increasingly used in biological studies to allow SICM
Bing-Chen eLiu +7 more
doaj +1 more source
New aspects of HERG K⁺ channel function depending upon cardiac spatial heterogeneity. [PDF]
PLoS ONE, 2014 HERG K(+) channel, the genetic counterpart of rapid delayed rectifier K(+) current in cardiac cells, is responsible for many cases of inherited and drug-induced long QT syndromes.
Pen Zhang +3 more
doaj +1 more source
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Planar Patch Clamp and Techniques of Patch-Clamp Spectroscopy in Antimicrobial Therapy
Austin Journal of Pharmacology and Therapeutics, 2023 Planar patch-clamp is an effective screening tool in pharmacology, institutionalized in molecular microbiology over 15 years ago [1]. The creation of planar polymer patch-clamp electrodes and silicon substrates in the 2000s [2,3] and the creation of microfluidic chips and perfusable chambers corresponding to this pharmacological screening technology ...
Orehow F, Adamovic E, Gradow O
openaire +1 more source
Advanced Engineering Materials, EarlyView.The release of foulers from protective marine coatings is determined by several interrelated material properties, including the strength of Young's modulus, the flexibility of chain segments, the surface free energy, and the magnitude of hydrodynamic stress.
Johann C. Schaal +2 more
wiley +1 more source
Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations. [PDF]
PLoS ONE, 2012 BACKGROUND: Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorders. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant inherited ion channel disorder predominantly caused by ...
Kirsi Kujala +12 more
doaj +1 more source
Experimental Analysis and Physics‐Based Analytical Model on Twisted and Coiled Artificial Muscles
Advanced Engineering Materials, EarlyView.Twisted and coiled artificial muscles made from silver‐coated nylon fibers are investigated through experiments and analytical modeling. The actuators achieve contractions up to 19.3% and specific work of 8 kJ kg−1, though efficiency remains limited (≈0.15%) by thermal losses.
Salvatore Garofalo +3 more
wiley +1 more source
Journal of Toxicology, 2012 Nervous system of Periplaneta americana cockroach is used in a wide range of pharmacological studies, including electrophysiological techniques. This paper presents its role as a preparation in the development of toxinological studies in the following ...
Maria Stankiewicz +2 more
doaj +1 more source