Results 41 to 50 of about 3,743,609 (282)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Implementation of Nonlinear Model Predictive Path-Following Control for an Industrial Robot

open access: yes, 2015
Many robotic applications, such as milling, gluing, or high precision measurements, require the exact following of a pre-defined geometric path. In this paper, we investigate the real-time feasible implementation of model predictive path-following ...
Faulwasser, Timm   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Contour Following for Scanning Control in SFF Application : Control Trajectory Planning [PDF]

open access: yes, 1990
Geometric contour following for scanning control in SFF application is used to refine the boundary ofthe parts for increasing the accuracy or to develop the capability to arrange various scanning directions and paths for improving the part strength ...
Beaman, J.J., Wu, Ying-Jeng Engin
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Pre-Filtered Backstepping Control for Underactuated Ship Path Following

open access: yesPolish Maritime Research, 2019
Robust path following control for underactuated surface ships is an important issue in marine control practice. This paper aims to improve the robustness of the close-loop system with model uncertainties and time-varying disturbances.
Liu Zhiquan
doaj   +1 more source

Neural Network-Based Adaptive Sigmoid Circular Path-Following Control for Underactuated Unmanned Surface Vessels under Ocean Disturbances

open access: yesJournal of Marine Science and Engineering, 2023
This study describes a circular curve path-following controller for an underactuated unmanned surface vessel (USV) experiencing unmodeled dynamics and external disturbances. Initially, a three degrees of freedom kinematic model of the USV is proposed for
Yi Ren, Lei Zhang, Wenbin Huang, Xi Chen
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Integration of Payload Sensors to Enhance UAV-Based Spraying

open access: yesDrones
This work focuses on the use of load sensors to help with spraying tasks using unmanned aerial vehicles (UAVs). The study details the construction of a prototype for load measurement to validate the proof of concept.
Celso O. Barcelos   +4 more
doaj   +1 more source

Adaptive LOS Path Following for a Podded Propulsion Unmanned Surface Vehicle with Uncertainty of Model and Actuator Saturation

open access: yesApplied Sciences, 2017
This paper addresses three related issues concerning the path following control of a podded propulsion unmanned surface vehicle (USV), namely modeling, guidance and control.
Dongdong Mu   +4 more
doaj   +1 more source

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