Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent [PDF]
Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta knockout mice were ...
A Ito +57 more
core +19 more sources
Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe +100 more
core +1 more source
A strong immune response in young adult honeybees masks their increased susceptibility to infection compared to older bees [PDF]
Honeybees, Apis mellifera, show age-related division of labor in which young adults perform maintenance ("housekeeping") tasks inside the colony before switching to outside foraging at approximately 23 days old. Disease resistance is an important feature
Baxter, Laura +8 more
core +8 more sources
Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands
The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor able to recognize both damage-associated and pathogen-associated molecular patterns, and in this respect, there has been much interest in determining the scope of ligands ...
Chriselle D. Braganza +7 more
doaj +1 more source
The destructive citrus pathogen, 'Candidatus Liberibacter asiaticus' encodes a functional flagellin characteristic of a pathogen-associated molecular pattern. [PDF]
Huanglongbing (HLB) is presently the most devastating citrus disease worldwide. As an intracellular plant pathogen and insect symbiont, the HLB bacterium, 'Candidatus Liberibacter asiaticus' (Las), retains the entire flagellum-encoding gene cluster in ...
Huasong Zou +5 more
doaj +1 more source
Do Mast Cells Contribute to the Antifungal Host Defense?
The fungal kingdom includes a group of microorganisms that are widely distributed in the environment, and therefore the exposure to them is almost constant.
Paulina Żelechowska +3 more
doaj +1 more source
High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]
The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon +68 more
core +1 more source
The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity [PDF]
Plant NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), produce reactive oxygen species (ROS) that perform a wide range of functions.
Antonio Molina +6 more
core +1 more source
Due to the global crisis caused by the dramatic rise of drug resistance among Gram-negative bacteria, there is an urgent need for a thorough understanding of the pathogenesis of infections of such an etiology.
Karolina Sidor, Tomasz Skirecki
doaj +1 more source
Carbonic anhydrases CA1 and CA4 function in atmospheric CO2-modulated disease resistance [PDF]
Main conclusion Carbonic anhydrases CA1 and CA4 attenuate plant immunity and can contribute to altered disease resistance levels in response to changing atmospheric CO2 conditions.
Pieterse, Corné M. J. +6 more
core +2 more sources

