Results 31 to 40 of about 218,478 (251)

Central Role for MyD88 in the Responses of Microglia to Pathogen-Associated Molecular Patterns [PDF]

The Journal of Immunology, 2006
Abstract Microglia, the innate immune effector cells of the CNS parenchyma, express TLR that recognize conserved motifs of microorganisms referred to as pathogen-associated molecular patterns (PAMP). All TLRs identified to date, with the exception of TLR3, use a common adaptor protein, MyD88, to transduce activation signals. Recently, we
Nilufer, Esen, Tammy, Kielian
openaire   +2 more sources

Activation and regulation mechanisms of NOD-like receptors based on structural biology

Frontiers in Immunology, 2022
Innate immunity is a primary defense system against microbial infections. Innate immune pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens.
Umeharu Ohto
doaj   +1 more source

Identification of Nicotiana benthamiana Genes Involved in Pathogen-Associated Molecular Pattern–Triggered Immunity

Molecular Plant-Microbe Interactions, 2010
In order to identify components of pathogen-associated molecular pattern–triggered immunity (PTI) pathways in Nicotiana benthamiana, we conducted a large-scale forward-genetics screen using virus-induced gene silencing and a cell-death-based assay for ...
Suma Chakravarthy, André C. Velásquez, Sophia K. Ekengren, Alan Collmer, Gregory B. Martin   +4 more
doaj   +1 more source

Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion

Nature Communications, 2019
The authors show that the fungal pathogen Candida albicans exploits diverse host-associated signals, including specific nutrients and stresses, to promote immune evasion by masking cell wall β-glucan, a major pathogen-associated molecular pattern.
Arnab Pradhan, Gabriela M. Avelar, Judith M. Bain, Delma Childers, Chloe Pelletier, Daniel E. Larcombe, Elena Shekhova, Mihai G. Netea, Gordon D. Brown, Lars Erwig, Neil A. R. Gow, Alistair J. P. Brown   +11 more
doaj   +1 more source

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death

Frontiers in Immunology, 2021
Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger ...
Thibault Roudaire, Marie-Claire Héloir, David Wendehenne, Aymeric Zadoroznyj, Aymeric Zadoroznyj, Laurence Dubrez, Laurence Dubrez, Benoit Poinssot   +7 more
doaj   +1 more source

ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori. [PDF]

FASEB J, 2019
ABSTRACT The gastric pathogen Helicobacter pylori activates the NF‐κB pathway in human epithelial cells via the recently discovered α‐kinase 1 TRAF‐interacting protein with forkhead‐associated domain (TIFA) axis.
Pfannkuch L, Hurwitz R, Traulsen J, Sigulla J, Poeschke M, Matzner L, Kosma P, Schmid M, Meyer TF.   +8 more
europepmc   +4 more sources

Pathogen-Associated Molecular Pattern-Triggered Immunity: Veni, Vidi…?

Plant Physiology, 2010
For many years, plant pathology was divided into two schools of thought. It was clear that purified molecules or crude extracts from microbes or plants (referred to as general elicitors) could induce activation of general defense responses ([Boller, 1995][1]).
Zipfel, Cyril, Robatzek, Silke
openaire   +5 more sources

DAMPs and Innate Immune Training

Frontiers in Immunology, 2021
The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the ...
Elisa Jentho, Elisa Jentho, Sebastian Weis, Sebastian Weis   +3 more
doaj   +1 more source

Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns

Nature Communications, 2022
AbstractThe formyl peptide receptor 1 (FPR1) is primarily responsible for detection of short peptides bearing N-formylated methionine (fMet) that are characteristic of protein synthesis in bacteria and mitochondria. As a result, FPR1 is critical to phagocyte migration and activation in bacterial infection, tissue injury and inflammation.
Geng Chen, Xiankun Wang, Qiwen Liao, Yunjun Ge, Haizhan Jiao, Qiang Chen, Yezhou Liu, Wenping Lyu, Lizhe Zhu, Gydo C. P. van Zundert, Michael J. Robertson, Georgios Skiniotis, Yang Du, Hongli Hu, Richard D. Ye   +14 more
openaire   +3 more sources

NLRP3: Role in ischemia/reperfusion injuries

Frontiers in Immunology, 2022
NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome.
Soudeh Ghafouri-Fard, Hamed Shoorei, Hamed Shoorei, Yadollah Poornajaf, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Yasaman Hajiesmaeili, Atefe Abak, Mohammad Taheri, Mohammad Taheri, Ahmad Eghbali   +10 more
doaj   +1 more source