Results 11 to 20 of about 110,723 (225)
Therapeutic Interventions into Innate Immune Diseases by Means of Aptamers
Pharmaceutics, 2020 The immune system plays a crucial role in the body’s defense system against various pathogens, such as bacteria, viruses, and parasites, as well as recognizes non-self- and self-molecules.
Farzana Yasmeen +4 more
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Innate Immune Recognition: An Issue More Complex Than Expected
Frontiers in Cellular and Infection Microbiology, 2019 Primary interaction of an intracellular bacterium with its host cell is initiated by activation of multiple signaling pathways in response to bacterium recognition itself or as cellular responses to stress induced by the bacterium.
Klara Kubelkova, Ales Macela
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Tongue sole creatine kinases function as DAMP and activate antimicrobial immunity via TLR2
Frontiers in Immunology, 2023 Creatine kinase (CK) is an enzyme that regulates adenosine triphosphate (ATP) metabolism to maintain energy homeostasis. Although CK has been reported to be involved in pathogen infection, the immune function of CK remains elusive.
Xin Li +8 more
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Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
Frontiers in Immunology, 2017 Inflammation is increasingly implicated in neurodegenerative disease pathology. As no acquired pathogen appears to drive this inflammation, the question of what does remains.
Russell H. Swerdlow +9 more
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Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
Frontiers in Immunology, 2018 Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular ...
Gustavo P. Amarante-Mendes +9 more
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Platelet Inflammatory Response to Stress
Frontiers in Immunology, 2019 Blood platelets play a central hemostatic role, (i) as they repair vascular epithelial damage, and (ii) they play immune defense roles, as they have the capacity to produce and secrete various cytokines, chemokines, and related products.
Fabrice Cognasse +14 more
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The rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdown
Clinical & Translational Immunology, 2020 The nod‐like receptor protein 3 (NLRP3) inflammasome drives inflammation in response to mitochondrial dysfunction. As metabolic powerhouses with prokaryotic ancestry, mitochondria are a cache for danger‐associated molecular patterns and pathogen ...
Caroline L Holley, Kate Schroder
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Mediators of Inflammation, 2010 In order to establish an infection, viruses need to either suppress or escape from host immune defense systems. Recent immunological research has focused on innate immunity as the first line of host defense, especially pattern recognition molecules such ...
Shin-ichi Yokota +2 more
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Frontiers in Plant Science, 2017 Microbial pathogens have evolved protein effectors to promote virulence and cause disease in host plants. Pathogen effectors delivered into plant cells suppress plant immune responses and modulate host metabolism to support the infection processes of ...
Nam-Soo Jwa, Byung Kook Hwang
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The role of toll-like receptors in peptic ulcer disease
Immunological Medicine, 2021 Helicobacter pylori (HP) is the primary etiologic factor that induces events in the immune system that lead to peptic ulcers. Toll-like receptors (TLRs) are an important part of the innate immune system, as they play pivotal roles in pathogen-associated ...
Shizhu Jin, Narayan Nepal, Yang Gao
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