Results 21 to 30 of about 110,723 (225)
Toll-Interacting Protein in Resolving and Non-Resolving Inflammation
Frontiers in Immunology, 2017 Innate leukocytes manifest dynamic and distinct inflammatory responses upon challenges with rising dosages of pathogen-associated molecular pattern molecules such as lipopolysaccharide (LPS).
Elizabeth J. A. Kowalski, Liwu Li
doaj +1 more source
Nuclear Alarmin Cytokines in Inflammation
Journal of Immunology Research, 2020 Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and ...
Lili Jiang +4 more
doaj +1 more source
Immune functions of pattern recognition receptors in Lepidoptera
Frontiers in Immunology, 2023 Pattern recognition receptors (PRRs), as the “sensors” in the immune response, play a prominent role in recognizing pathogen-associated molecular patterns (PAMPs) and initiating an effective defense response to pathogens in Lepidoptera.
Lin Zhao +4 more
doaj +1 more source
Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?
Molecular Medicine, 2020 Background The 2019 novel coronavirus disease (COVID-19) causes for unresolved reasons acute respiratory distress syndrome in vulnerable individuals. There is a need to identify key pathogenic molecules in COVID-19-associated inflammation attainable to ...
Ulf Andersson +2 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Journal of Medical Microbiology and Infectious Diseases, 2020 Introduction: Coronavirus infectious disease 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pathogen-associated molecular patterns (PAMPs) can be detected by host pattern-recognition receptors
Hossein Teimouri, Amirhosein Maali
doaj
Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?
Mediators of Inflammation, 2016 Inflammation is a protective response of the organism to tissue injury or infection. It occurs when the immune system recognizes Pathogen-Associated Molecular Patterns (PAMPs) or Damage-Associated Molecular Pattern (DAMPs) through the activation of ...
Gloria Lopez-Castejon +1 more
doaj +1 more source
The molecular pathways underlying host resistance and tolerance to pathogens
Frontiers in Genetics, 2012 Breeding livestock that are better able to withstand the onslaught of endemic and exotic pathogens is high on the wish list of breeders and farmers world-wide.
Elizabeth Janet Glass
doaj +1 more source