Results 31 to 40 of about 110,723 (225)

Nontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates. [PDF]

PLoS ONE, 2011
Non-typable Haemophilus influenzae (NTHi) is a gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the existence of a remarkable genetic
Pau Martí-Lliteras, Antonio López-Gómez, Silvia Mauro, Derek W Hood, Cristina Viadas, Laura Calatayud, Pau Morey, Alain Servin, Josefina Liñares, Antonio Oliver, José Antonio Bengoechea, Junkal Garmendia   +11 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Pathogens and Dead Cells Cooperate with Cytokines in Activating the Innate and Adaptive Response

European Journal of Inflammation, 2011
After microbial invasion and tissue damage, a set of cytokines, including interleukin-1α (IL-1α), IL-1β, IL-6, IL-18 and tumor necrosis factor-α (TNF-α), and microbial and endogenous molecules named pathogen-associated molecular pattern (PAMPs) and ...
J.E. Belizário
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Uncovering the Mechanisms: The Role of Biotrophic Fungi in Activating or Suppressing Plant Defense Responses

Journal of Fungi
This paper discusses the mechanisms by which fungi manipulate plant physiology and suppress plant defense responses by producing effectors that can target various host proteins.
Michel Leiva-Mora, Yanelis Capdesuñer, Ariel Villalobos-Olivera, Roberto Moya-Jiménez, Luis Rodrigo Saa, Marcos Edel Martínez-Montero   +5 more
doaj   +1 more source

The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure

Mediators of Inflammation, 2018
Medical systems worldwide are being faced with a growing need to understand mechanisms behind the pathogenesis of heart failure (HF) that is considered as a leading cause of morbidity and mortality around the world.
Lili Yu, Zhiwei Feng
doaj   +1 more source

Regulation of NLRP3 Inflammasome by Phosphorylation

Frontiers in Immunology, 2018
The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Nan Song, Nan Song, Tao Li, Tao Li
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Toll-Like Receptors in Liver Fibrosis: cellular crosstalk and mechanisms

Frontiers in Physiology, 2012
Toll-like receptors (TLRs) are pattern recognition receptors that distinguish conserved microbial products, also known as pathogen-associated molecular patterns (PAMPs), from host molecules.
Ling eYang, Ekihiro eSeki
doaj   +1 more source

Mechanism of Innate Immune Responses Against SARS-COV-2 Infection

Zanco Journal of Pure and Applied Sciences, 2023
The immunopathogenesis of the Coronaviruses (CoVs) is still under study. The innate immunity components can differentiate self and non-self-antigens, be involved in viral particle recognition, and restrict viral replications through antiviral protein ...
Hiwa Abdulrahman Ahmad, Khalat Karwan Fares   +1 more
doaj   +1 more source