Results 51 to 60 of about 256,778 (292)
When the infectious environment meets the AD brain
Molecular Neurodegeneration, 2022 Background The Amyloid theory of Alzheimer’s disease (AD) suggests that the deposition of Amyloid β (Aβ) in the brain triggers a chain of events, involving the deposition of phosphorylated Tau and other misfolded proteins, leading to neurodegeneration ...
Tal Ganz, Nina Fainstein, Tamir Ben-Hur
doaj +1 more source
Variation in resistance to multiple pathogen species:anther-smuts of Silene uniflora [PDF]
, 2012 The occurrence of multiple pathogen species on a shared host species is unexpected when they exploit the same micro-niche within the host. One explanation for such observations is the evolution of pathogen-specific resistances that segregate the host ...
Pedersen, Amy +4 more
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Development of the immune response in pneumonia due to Staphylococcus aureus (part 1)
Zdorovʹe Rebenka, 2017 The literature review presents modern data on the pathogen-associated molecular structures of Staphylococcus aureus and its role in the occurrence of pneumonia: activation and modulation of the immune response, oxidative and metabolic stress, apoptosis ...
A.E. Abaturov, A.A. Nikulinа
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis
Journal of Intensive Care, 2017 Background Sepsis is one of the most significant causes of mortality in intensive care units. It indicates crosstalk between inflammation and coagulation.
Kota Hoshino +6 more
doaj +1 more source
NLRP3: Role in ischemia/reperfusion injuries
Frontiers in Immunology, 2022 NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome.
Soudeh Ghafouri-Fard +10 more
doaj +1 more source
Pathogen Associated Molecular Patterns, Pattern Recognition Receptors and Pediatric Sepsis [PDF]
The Open Inflammation Journal, 2011 The mortality of septic shock in the pediatric population has improved over the last 2 decades with better supportive care however it still remains unacceptably high. Exaggerated inflammatory responses early in septic shock have been associated with poor outcomes.
openaire +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Molecular Plant-Microbe Interactions, 2006 Nonspecific recognition of pathogen-derived general elicitors triggers the first line of plant basal defense, which in turn, preconditions the host towards resistance or susceptibility. To elucidate how basal defense responses influence the onset of Mla (
Rico A. Caldo +3 more
doaj +1 more source