Results 71 to 80 of about 258,381 (291)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

PAMPs of Piscirickettsia salmonis Trigger the Transcription of Genes Involved in Nutritional Immunity in a Salmon Macrophage-Like Cell Line

Frontiers in Immunology, 2022
The innate immune system can limit the growth of invading pathogens by depleting micronutrients at a cellular and tissue level. However, it is not known whether nutrient depletion mechanisms discriminate between living pathogens (which require nutrients)
Danixa Pamela Martínez, Danixa Pamela Martínez, Cristian Oliver, Natacha Santibañez, José Leonardo Coronado, Ricardo Oyarzún-Salazar, Ricardo Enriquez, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Alex Romero, Alex Romero   +11 more
doaj   +1 more source

The role of BRI1-associated kinase 1 (BAK1) in the regulation of plant innate immunity : functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana [PDF]

, 2014
The role of BRI1-ASSOCIATED KINASE 1 (BAK1) in the regulation of plant innate immunity: functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana SUMMARY BAK1 (BRI1-ASSOCIATED KINASE 1) is an intensively studied member ...
Kiss-Papp, Márta
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

Frontiers in Immunology, 2021
EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria.
Kuan-Yu I, Wen-Yi Tseng, Wen-Chih Wang, Siamon Gordon, Siamon Gordon, Kwai-Fong Ng, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin   +8 more
doaj   +1 more source

Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy [PDF]

Cancer Gene Therapy, 2008
The delivery of stimulatory signals to dendritic cells (DCs) in the tumor microenvironment could be an effective means to break tumor-induced tolerance. The work presented here evaluates the immunostimulatory properties of pathogen-associated molecular patterns (PAMPs), microbial molecules which bind Toll-like receptors and deliver activating signals ...
C, Tosch, M, Geist, C, Ledoux, C, Ziller-Remi, S, Paul, P, Erbs, N, Corvaia, P, Von Hoegen, J-M, Balloul, H, Haegel   +9 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The Etiopathogenesis of Kawasaki Disease: Evolving Understanding of Diverse Triggers

Immunity, Inflammation and Disease
Background Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Evidence suggests that microbial and nonmicrobial triggers for KD differ across geographical regions and environmental conditions.
Toshiro Hara, Yasunari Sakai
doaj   +1 more source

Assay for Pathogen-Associated Molecular Pattern (PAMP)-Triggered Immunity (PTI) in Plants [PDF]

Journal of Visualized Experiments, 2009
To perceive potential pathogens in their environment, plants use pattern recognition receptors (PRRs) present on their plasma membranes. PRRs recognize conserved microbial features called pathogen-associated molecular patterns (PAMPs) and this detection leads to PAMP-triggered immunity (PTI), which effectively prevents colonization of plant tissues by ...
Chakravarthy, Suma, Velásquez, André C., Martin, Gregory B.   +2 more
openaire   +2 more sources

Neutral Genomic Microevolution of a Recently Emerged Pathogen, Salmonella enterica Serovar Agona [PDF]

, 2013
Salmonella enterica serovar Agona has caused multiple food-borne outbreaks of gastroenteritis since it was first isolated in 1952. We analyzed the genomes of 73 isolates from global sources, comparing five distinct outbreaks with sporadic infections as ...
Eva Litrup (404346), Murphy, Ronan, Fanning, S, Mark Achtman, Angela McCann (404345), Sylvain Brisse (87594), Brown, D, Zhou, Z, Cormican, Martin, Brisse, Sylvain, Mark Achtman (126786), Guttman, David S., Zhemin Zhou (157214), Ronan Murphy (404347), Brown, Derek, Litrup, Eva, Seamus Fanning (5651275), McCann, Angela, Brisse, S, David S. Guttman (131322), Achtman, Mark, McCann, A, Derek Brown (404349), Sylvain Brisse, Zhou, Zhemin, Litrup, E, Murphy, R, Angela McCann, Zhemin Zhou, David S Guttman, Martin Cormican, Guttman, DS, Eva Litrup, Ronan Murphy, Seamus Fanning, Derek Brown, Fanning, Seamus, Achtman, M, Cormican, M, Martin Cormican (404348)   +39 more
core   +1 more source