Results 91 to 100 of about 258,381 (291)

Understanding the molecular epidemiology of the footrot pathogen Dichelobacter nodosus to support control and eradication programs [PDF]

, 2010
The Gram-negative anaerobe Dichelobacter nodosus is the primary etiologic agent of ovine footrot. Few studies of the genetic diversity and epidemiology of D. nodosus have been done, despite the economic cost and welfare implications of the disease.
Pitman, D., D. J. Hampson, Palmer, M., Hampson, D.J., N. B. Buller, Ashley, P., D. Pitman, R. B. Richards, Buller, N. B., Richards, R. B., P. Ashley, M. Palmer   +11 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Frontiers in Immunology, 2018
Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host ...
Tomoya Hayashi, Tomoya Hayashi, Masatoshi Momota, Masatoshi Momota, Etsushi Kuroda, Etsushi Kuroda, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Ken J. Ishii, Hidetoshi Arima, Hidetoshi Arima   +22 more
doaj   +1 more source

ADP-heptose is a pathogen-associated molecular pattern of Shigella flexneri infection [PDF]

, 2018
ABSTRACT During an infection, the detection of pathogens is mediated through interactions between pathogen-associated molecular patterns (PAMPs) and pathogen recognition receptors. β-Heptose 1,7-bisphosphate (βHBP), a metabolite of the lipopolysaccharide (LPS) biosynthesis pathway, was recently identified as a PAMP of
García-Weber, Diego, Dangeard, Anne-Sophie, Cornil, Johan, Thai, Linda, Rytter, Héloise, Mulard, Laurence A., Arrieumerlou, Cécile   +6 more
openaire   +1 more source

Hierarchy and Roles of Pathogen-Associated Molecular Pattern-Induced Responses in Nicotiana benthamiana     [PDF]

Plant Physiology, 2011
Abstract Our current understanding of pathogen-associated molecular pattern (PAMP)-triggered immunity signaling pathways in plants is limited due to the redundancy of several components or the lethality of mutants in Arabidopsis (Arabidopsis thaliana). To overcome this, we used a virus-induced gene silencing-based approach in combination
Segonzac, Cécile, Feike, Doreen, Gimenez-Ibanez, Selena, Hann, Dagmar R, Zipfel, Cyril, Rathjen, John P   +5 more
openaire   +4 more sources

Genomic relatedness within five common Finnish Campylobacter jejuni pulsed-field gel electrophoresis genotypes studied by amplified fragment length polymorphism analysis, ribotyping and serotyping [PDF]

, 2001
Thirty-five Finnish Campylobacter jejuni strains with five SmaI/SacII pulsed-field gel electrophoresis (PFGE) genotypes selected among human and chicken isolates from 1997 and 1998 were used for comparison of their PFGE patterns, amplified fragment ...
Hanninen, M.L., Wagenaar, J.A., Rautelin, H., Perko Makela, P., Duim, B.   +4 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Rostislav Skrabana, Michal Novak, Mangesh Bhide, Ivan Mikula Jr., Rastislav Mucha, Lucia Kisova, Ivan Mikula Sr.   +6 more
core   +1 more source

Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models [PDF]

, 2010
We attached the pathogen associated molecular pattern Kdo2-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli.
Tom A. Barr, Juan C. Mareque-Rivas, Gray, David, Barr, Tom A., Martin Krembuszewski, Barr, T.A., Gupta, Manish, Mareque-Rivas, Juan C., Krembuszewski, M., Manish Gupta, Krembuszewski, Martin, Gray, D., David Gray, Mareque-Rivas, J.C., Gupta, M.   +14 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source