Results 91 to 100 of about 256,778 (292)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Taking its TOLL: the role of toll-like receptor 4 in human health and disease, and its potential as a therapeutic target

Frontiers in Immunology
Toll-like receptor 4 (TLR4) is a pattern recognition receptor that binds to pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs). Binding of exogenous or endogenous ligands activates the TLR4 pathway and induces
Phoebe Crammond, Priyanka Hastak, Anthony Delaney, Anthony Delaney, Sarah C. Sasson   +4 more
doaj   +1 more source

Emergence and global spread of epidemic healthcare-associated clostridium difficile [PDF]

, 2012
Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global ...
Hawkey, P.r, Brazier, Jon, Martin, Melissa J, Fairley, Derek, Brown, D., Kim, H.J., Kuijper, Ed, Kato, Haru, Coia, JE, Kathleen B Bamford, Tse Hsien Koh, Kim, HJ, He, M., Wren, B.W., Miyajima, Fabio, Riley, Tom, Brazier, J. S., Kato, H., Harris, Simon R, D'Arc, S., Butt, E., Nick M Brown, Gerding, D, Martin, M.J., Wren, BW, Paul Roberts, Douce, G, Pirmohamed, M, Munir Pirmohamed, Louise Ellison, Songer, Glen, Songer, G, Coia, John E., He, M, Brendan W Wren, Douce, Gill, Kuijper, E., Sharon J Peacock, Pickard, Derek J, Butt, Emma, Mark Wilcox, Lawley, Trevor D, Dale Gerding, Wren, Brendan W, Songer, G., Senoh, Mitsutoshi, Haru Kato, Mitsutoshi Senoh, D'Arc, S, Hee Jung Kim, Pirmohamed, M., Connor, Thomas Richard, Ellison, Louise, Brown, Nick M, Wilcox, Mark, Miyajima, F, Pickard, Derek J., Harris, S.R., Roberts, Paul, Koh, Tse Hsien, Melissa J Martin, Julian Parkhill, Hawkey, P., Louie, T., Bamford, KB, Coia, J., Dougan, Gordon, Coia, John E, Parkhill, Julian, Hawkey, P, Ed Kuijper, Bamford, Kathleen B., Thomas R Connor, Gill Douce, Glen Songer, Pickard, D.J., Simon R Harris, Tom Louie, Derek Fairley, Fairley, D, Miyajima, F., Wilcox, M, Parkhill, J, Michell, S., Tom Riley, Louie, Tom, Harris, Simon R., Louie, T, Lawley, T.D., Bamford, K.B., He, Miao, Gerding, Dale, Connor, T.R., Peacock, Sharon J., Kuijper, E, Butt, E, Peacock, SJ, Brown, Derek, Senoh, M., Gordon Dougan, Pirmohamed, Munir, Gerding, D., Ellison, L, Peter Hawkey, Koh, T.H., Harris, SR, Brazier, J., Wilcox, M., Trevor D Lawley, Coia, J.E., Emma Butt, Ellison, L., Peacock, Sharon J, Brown, NM, Michell, S, Derek Brown, Derek J Pickard, Brown, Nick M., 김희정, Martin, MJ, Peacock, S.J., Brown, N.M., Dougan, G., Brown, D, Riley, T., Kim, Hee Jung, Brazier, J, Kato, H, Connor, Thomas R, Fairley, D., Parkhill, J., Stephanie D'Arc, Wren, Brendan W., D'Arc, Stephanie, Douce, G., Lawley, TD, John E Coia, Fabio Miyajima, Michell, Stephen, Jon Brazier, Lawley, Trevor D., Martin, Melissa J., Miao He, Stephen Michell, Roberts, P., Koh, TH, Hawkey, Peter, Pickard, DJ, Bamford, Kathleen B, Douce, G.l, Roberts, P, Riley, T, Connor, TR, Senoh, M, Dougan, G   +154 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Characterization of the West Nile virus pathogen associated molecular patterns [PDF]

, 2013
The recent emergence of West Nile virus (WNV) in the western hemisphere has been marked by an increase in severe neurological disease. The factors that contribute to this increase in pathogenicity are poorly understood, however, there is evidence that ...
German, Jennifer
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
McLellan, Hazel, Remco eStam, Gaëtan eThilliez, Remco Stam, Thilliez, Gaëtan, Gaëtan Thilliez, Sophie Mantelin, Hazel eMcLellan, Hazel McLellan, Stam, Remco, Mantelin, Sophie, Sophie eMantelin   +11 more
core   +1 more source

Pathogen Associated Molecular Pattern Recognition in Innate Immunity

Ensho Saisei, 2003
Toll-like receptors (TLRs) play a critical role in the detection of invading pathogens and subsequent immune response against them. Individual TLRs recognize distinct microbial components. The TLR is a type 1 transmembrane receptor that is composed of an extracellular leucine-rich repeat (LRR) domain and cytoplasmic domain homologous to that of the IL ...
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source