Results 101 to 110 of about 256,778 (292)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses

Cell Reports, 2017
It is currently unknown whether and how mammalian pathogen recognition receptors (PRRs) respond to biophysical patterns of pathogen-associated molecular danger signals.
Jardin A. Leleux, Pallab Pradhan, Krishnendu Roy   +2 more
doaj   +1 more source

Low Diversity Cryptococcus neoformans Variety grubii Multilocus Sequence Types from Thailand Are Consistent with an Ancestral African Origin [PDF]

, 2011
The global burden of HIV-associated cryptococcal meningitis is estimated at nearly one million cases per year, causing up to a third of all AIDS-related deaths.
Fisher, M.D., Annemarie E. Brouwer, Thomas S Harrison, Simwami, SP, Matthew C Fisher, Boekhout, T, Khayhan Kantarawee, Aanensen, D.M., Brouwer Annemarie E., Hagen, F, Daniel A Henk, Matthew C. Fisher, Harrison, T.S., Henk Daniel A., Donnelly Christl A., Harrison Thomas S., Fisher Matthew C., Khayhan, K., David M. Aanensen, Aanensen David M., Annemarie E Brouwer, Brouwer, A.E., Donnelly, C.A., Aanensen, DM, Christl A Donnelly, Henk, DA, Brouwer, AE, Hagen, F., Henk, D.A., Sitali P. Simwami, Sitali P Simwami, Khayhan, K, Donnelly, CA, Ferry Hagen, Daniel A. Henk, Fisher, MC, Christl A. Donnelly, Teun Boekhout, Hagen Ferry, Kantarawee Khayhan, Simwami Sitali P., Boekhout, T., Boekhout Teun, Harrison, TS, Thomas S. Harrison, Simwami, S.P., David M Aanensen   +46 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Characterization of the strawberry pathogen Gnomonia fragariae, and biocontrol possibilities [PDF]

, 2006
The strawberry root rot complex or black root rot is common and increasing problem in perennial strawberry plantings worldwide. In many cases the causes of root rot are not detected or it is referred to several pathogens.
Moročko, Inga
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]

, 2010
. We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Te Lintel Hekkert, B., S.B. Goodwin, Zapater, Marie-Françoise, Goodwin,, Stephen B., Lee, T.A.J., van der, M. Guzm�n, S.A.L. Garcia, Kema, G.H.J., Ferreira, C.F., Van der Lee, Theo A.J., C.F. Ferreira, Zapater, M.F., Ferreira, Claudia Fortes, M.-F. Zapater, T.A.J. Van der Lee, Souza, M.T., Kema, Gert H.J., Garcia, S.A.L., B. Te Lintel Hekkert, Guzmán, M., M.T. Souza Jr., Goodwin, S.B., Goodwin, Stephen B., G.H.J. Kema, Lintel Hekkert, B., te, van der Lee, T.A.J.   +25 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sensing of Ebinur Lake virus by distinct pattern recognition receptors dictates cell-type specific innate immunity and pathogenesis

Journal of Virology
Ebinur Lake virus (EBIV) is a recently identified orthobunyavirus with broad host range and zoonotic potential, posing a public health risk. However, the mechanisms underlying EBIV pathogenesis and host innate immune responses remain unclear.
Jia-Peng Zou, Su-Yun Wang, Han Xia, Zhi-Sheng Xu, Wei-Wei Luo, Yan-Yi Wang   +5 more
doaj   +1 more source