Results 111 to 120 of about 258,381 (291)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Low Diversity Cryptococcus neoformans Variety grubii Multilocus Sequence Types from Thailand Are Consistent with an Ancestral African Origin [PDF]

, 2011
The global burden of HIV-associated cryptococcal meningitis is estimated at nearly one million cases per year, causing up to a third of all AIDS-related deaths.
Fisher, M.D., Annemarie E. Brouwer, Thomas S Harrison, Simwami, SP, Matthew C Fisher, Boekhout, T, Khayhan Kantarawee, Aanensen, D.M., Brouwer Annemarie E., Hagen, F, Daniel A Henk, Matthew C. Fisher, Harrison, T.S., Henk Daniel A., Donnelly Christl A., Harrison Thomas S., Fisher Matthew C., Khayhan, K., David M. Aanensen, Aanensen David M., Annemarie E Brouwer, Brouwer, A.E., Donnelly, C.A., Aanensen, DM, Christl A Donnelly, Henk, DA, Brouwer, AE, Hagen, F., Henk, D.A., Sitali P. Simwami, Sitali P Simwami, Khayhan, K, Donnelly, CA, Ferry Hagen, Daniel A. Henk, Fisher, MC, Christl A. Donnelly, Teun Boekhout, Hagen Ferry, Kantarawee Khayhan, Simwami Sitali P., Boekhout, T., Boekhout Teun, Harrison, TS, Thomas S. Harrison, Simwami, S.P., David M Aanensen   +46 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses

Cell Reports, 2017
It is currently unknown whether and how mammalian pathogen recognition receptors (PRRs) respond to biophysical patterns of pathogen-associated molecular danger signals.
Jardin A. Leleux, Pallab Pradhan, Krishnendu Roy   +2 more
doaj   +1 more source

Characterization of the strawberry pathogen Gnomonia fragariae, and biocontrol possibilities [PDF]

, 2006
The strawberry root rot complex or black root rot is common and increasing problem in perennial strawberry plantings worldwide. In many cases the causes of root rot are not detected or it is referred to several pathogens.
Moročko, Inga
core  

Engineering plant resistance by constructing chimeric receptors that recognize damage-associated molecular patterns (DAMPs) [PDF]

, 2011
An efficient sensing of danger and a rapid activation of the immune system are crucial for the survival of plants. Conserved pathogen/microbe-associated molecular patterns (PAMPs/MAMPs) and endogenous molecular patterns, which are present only when the ...
DE LORENZO, Giulia, Giulia De Lorenzo, SICILIA, Francesca, Daniel Valentin Savatin, Felice Cervone, SAVATIN, DANIEL VALENTIN, Francesca Sicilia, Brutus, Alexandre, CERVONE, Felice, Alexandre Brutus   +9 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]

, 2010
. We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Te Lintel Hekkert, B., S.B. Goodwin, Zapater, Marie-Françoise, Goodwin,, Stephen B., Lee, T.A.J., van der, M. Guzm�n, S.A.L. Garcia, Kema, G.H.J., Ferreira, C.F., Van der Lee, Theo A.J., C.F. Ferreira, Zapater, M.F., Ferreira, Claudia Fortes, M.-F. Zapater, T.A.J. Van der Lee, Souza, M.T., Kema, Gert H.J., Garcia, S.A.L., B. Te Lintel Hekkert, Guzmán, M., M.T. Souza Jr., Goodwin, S.B., Goodwin, Stephen B., G.H.J. Kema, Lintel Hekkert, B., te, van der Lee, T.A.J.   +25 more
core   +1 more source