Results 131 to 140 of about 258,381 (291)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceDistinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica [PDF]
, 2013 Peer ...Marco Mammella (421707), Julio C. Vega-Arreguin (421715), Horner, N. R., van Rooyen, D., Young, S. K., Guido van den Ackerveken (5650309), Stassen, J.H.M., Javier Dieguez-Uribeondo, Berg, H., Brett M. Tyler (19744), James Christie, Young, Sarah K, Grenville-Briggs, Laura J.,, Grenville-Briggs, L., Arnaud Bottin (41550), Elzbieta Rzeszutek (421711), Andrew J. Phillips (334915), Rooyen, D., van, van den Berg, H., Stan Oome (421709), Chad Nusbaum (253636), van den Berg, Herbert, Sarah K Young, Pieter van West (205267), Christie, James, Berend Snel, Rzeszutek, Elzbieta,, Lars Löbach, Horner, N.R., Díaz-Moreno, S.M., Sarah K. Young (178826), Morris, P., Seidl, M.F., de Bruijn, I., Joshua Z. Levin (177182), Levin, Joshua Z, Sucheta Tripathy, Meijer, Harold J. G., Grenville-Briggs, L. J., Secombes, Chris J, Secombes, Chris J., Grenville-Briggs, Laura J, Carsten Russ, Oome, Stan, Wawra, Stephan, Snel, Berend, Belmonte, Rodrigo, Mammella, M., Marcia Saraiva (421712), Elodie Gaulin (40047), Rodrigo Belmonte, Dieguez-Uribeondo, J., Marco Mammella, Sara M. Díaz-Moreno (421704), Qiandong Zeng (178764), Grenville-Briggs, L.J., Lin Fan (281949), Chad Nusbaum, Dumas, B., Levin, J.Z., Andrew J Phillips, Julio C Vega-Arreguin, Horner, Neil R, Sub Theoretical Biology & Bioinformatics, Haas, B., Dep Biologie, Tyler, Brett M., Meijer, H.J., van den Ackerveken, G., Löbach, Lars, Vega-Arreguin, Julio C, Russ, C., David van Rooyen, et al., Vega-Arreguin, Julio C., Bruijn, I., de, Govers, F., van West, Pieter, van den Ackerveken, A.F.J.M., Díaz-Moreno, S., Nusbaum, Chad, Chris J Secombes, Vega-Arreguin, J. C., Sub Plant-Microbe Interactions, Gaulin, Elodie, Sykes, Sean, Meijer, H.J.G., Irene de Bruijn, Seidl, Michael F., Wawra, S., Stassen, Joost H. M., Nusbaum, C., Paul Morris, Secombes, C.J., Stassen, Joost H M, Stephan Wawra, Laura J. Grenville-Briggs (421705), Bernard Dumas, Saraiva, M., Jiang, R., Phillips, Andrew J, Belmonte, R., Grenville-Briggs, Laura J., de Bruijn, Irene, Stan Oome, Haas, B. J., Harold J. G. Meijer (227595), Saraiva, Marcia, Qiandong Zeng, Rzeszutek, E., Stassen, J. H., Young, Sarah K., Young, S.K., Neil R Horner, Phillips, A. J., Joshua Z Levin, Jiang, R. H., Theoretical Biology and Bioinformatics, Stephan Wawra (421716), Joost H. M. Stassen (221771), David van Rooyen (421710), Bulone, Vincent, Irene de Bruijn (43879), van West, P., Sucheta Tripathy (19740), Secombes, C. J., Michael F. Seidl (221772), Snel, B., Levin, Joshua Z., Michael F Seidl, Gaulin, E., Bottin, A., Joost H M Stassen, Löbach, L., West, P., van, Bernard Dumas (40050), Díaz-Moreno, Sara M., Loebach, Lars, Guido van den Ackerveken, Lars Löbach (421702), Lin Fan, Haas, Brian J, Bulone, Vincent,, Herbert van den Berg, Jiang, Rays H. Y., Sean Sykes (158441), Vincent Bulone, Seidl, Michael F, Tripathy, S., Elzbieta Rzeszutek, Rzeszutek, Elzbieta, van Rooyen, David, Tyler, Brett M, Zeng, Qiandong, Levin, J. Z., Dieguez-Uribeondo, Javier, Morris, Paul, Díaz-Moreno, S. M., Govers, Francine, Tyler, B.M., Vincent Bulone (243055), Jiang, R.H.Y., Meijer, Harold J G, Marcia Saraiva, Neil R. Horner (421706), Arnaud Bottin, Meijer, H. J., Jiang, Rays H Y, Fan, Lin, Young, Sarah, Brett M Tyler, Bulone, V., Laura J Grenville-Briggs, Jiang, R.H.I., Elodie Gaulin, Horner, N., James Christie (421703), Tyler, B. M., Christie, J., Sean Sykes, de Haas, B.J., Sara M Díaz-Moreno, Francine Govers (52155), Francine Govers, Paul Morris (421708), van den Ackerveken, Guido, West, P., Oome, S., Berend Snel (5539), Zeng, Q., Haas, B.J., Chris J. Secombes (421713), Diaz-Moreno, Sara M.,, Vega-Arreguin, J.C., Javier Dieguez-Uribeondo (421717), Haas, Brian J., Fan, L., Carsten Russ (263594), Herbert van den Berg (421714), Sykes, S., Meijer, H., Stassen, J.H., Bottin, Arnaud, Horner, Neil R., Rays H Y Jiang, Ackerveken, G., van den, Russ, Carsten, Pieter van West, Levin, J., Rooyen, D., Plant Microbe Interactions, Harold J G Meijer, Rodrigo Belmonte (421701), Mammella, Marco, Phillips, Andrew J., Phillips, A.J., Brian J. Haas (81121), Rays H. Y. Jiang (421700), Seidl, M. F., Dumas, Bernard, Tripathy, Sucheta, Díaz-Moreno, Sara M, Brian J Haas +222 morecore +1 more sourceLoss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann +11 morewiley +1 more sourceCirculating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong +6 morewiley +1 more sourceThe Roles of Innate Immune Cells in Atopic Dermatitis
Journal of Innate ImmunityBackground: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patients’ life quality. Summary: AD has Yuke Pan, Youyi Wang, Meinian Xu, Meizhen Zhong, Xiaoming Peng, Kang Zeng, Xiaowen Huang +6 moredoaj +1 more sourceEpigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 morewiley +1 more source
