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A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood [PDF]

open access: yesEBioMedicine, 2016
Background: Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients.
Mark Cartwright   +17 more
doaj   +4 more sources

State of the Art of Innate Immunity—An Overview

open access: yesCells, 2022
The innate immune system is the first line of defense against bacterial and viral infections and sterile inflammation through the recognition of pathogen-associated molecular patterns (PAMPs) as well as danger-associated molecular patterns (DAMPs) by ...
Silvia Fischer, Elisabeth Deindl
doaj   +1 more source

Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions. Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and damage-associate molecular patterns (DAMPs) that are agonists for innate immune ...
Guang Han Ong   +3 more
doaj   +1 more source

Chromatin-Associated Molecular Patterns (CAMPs) in sepsis

open access: yesCell Death and Disease, 2022
Several molecular patterns have been identified that recognize pattern recognition receptors. Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are commonly used terminologies to classify molecules ...
Colleen P. Nofi, Ping Wang, Monowar Aziz
doaj   +1 more source

Effects of Harpin and Flg22 on Growth Enhancement and Pathogen Defense in Cannabis sativa Seedlings

open access: yesPlants, 2022
Pathogen-associated molecular patterns, PAMPs, are a diverse group of molecules associated with pathogenic microbes and are known to activate immune response and in some cases enhance growth in plants.
Lauren B. Sands   +4 more
doaj   +1 more source

Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms. [PDF]

open access: yesPLoS ONE, 2016
Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses.
Hirotsugu Hatai   +4 more
doaj   +1 more source

Molecular biology of autoinflammatory diseases

open access: yesInflammation and Regeneration, 2021
The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of various adaptive responses.
Junya Masumoto   +7 more
doaj   +1 more source

PAMPs and DAMPs as the Bridge Between Periodontitis and Atherosclerosis: The Potential Therapeutic Targets

open access: yesFrontiers in Cell and Developmental Biology, 2022
Atherosclerosis is a chronic artery disease characterized by plaque formation and vascular inflammation, eventually leading to myocardial infarction and stroke.
Xuanzhi Zhu, Hanyao Huang, Lei Zhao
doaj   +1 more source

Human Umbilical Cord Blood Mononuclear Cells Ameliorate CCl4-Induced Acute Liver Injury in Mice via Inhibiting Inflammatory Responses and Upregulating Peripheral Interleukin-22

open access: yesFrontiers in Pharmacology, 2022
Background: Human umbilical cord blood mononuclear cells (hUCBMNCs) show therapeutic effects on many inflammatory diseases. The deterioration of acute liver injury is attributed to excessive inflammatory responses triggered by damage-associated molecular
Jinming Zhang   +18 more
doaj   +1 more source

Characterization of the Xanthomonas campestris pv. campestris Lipopolysaccharide Substructures Essential for Elicitation of an Oxidative Burst in Tobacco Cells

open access: yesMolecular Plant-Microbe Interactions, 2005
The lipopolysaccharides (LPS) of gram-negative bacteria are essential for perception of pathogens by animals and plants. To identify the LPS substructure or substructures recognized by plants, we isolated water-phase (w)LPS from different Xanthomonas ...
Sebastian G. Braun   +4 more
doaj   +1 more source

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