Results 21 to 30 of about 44,783 (256)
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Using PAMPs and DAMPs as adjuvants in cancer vaccines
Human Vaccines & Immunotherapeutics, 2021 Immunotherapy for cancer has attracted considerable attention. As one of the immunotherapeutics, tumor vaccines exert great potential for cancer immunotherapy.
Huanyou Sun +10 more
doaj +1 more source
Various forms of tissue damage and danger signals following hematopoietic stem cell transplantation
Frontiers in Immunology, 2015 Hematopoietic stem cell transplantation (HSCT) is the most potent curative therapy for many malignant and non-malignant disorders. Unfortunately, a major complication of HSCT is graft-versus-host disease (GVHD), which is mediated by tissue damage ...
Abdulraouf eRamadan, Sophie ePaczesny
doaj +1 more source
The Role of Macrophages in the Host’s Defense against Sporothrix schenckii
Pathogens, 2021 The role of immune cells associated with sporotrichosis caused by Sporothrix schenckii is not yet fully clarified. Macrophages through pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns (PAMPs) of Sporothrix, engulf
Estela Ruiz-Baca +6 more
doaj +1 more source
PLoS ONE, 2014 Invertebrates rely on an innate immune system to combat invading pathogens. The system is initiated in the presence of cell wall components from microbes like lipopolysaccharide (LPS), β-1,3-glucan (βG) and peptidoglycan (PG), altogether known as pathogen-associated molecular patterns (PAMPs), via a recognition of pattern recognition protein (PRP) or ...
Yu-Yuan Chen +11 more
openaire +4 more sources
Danger Signals Activating the Immune Response after Trauma
Mediators of Inflammation, 2012 Sterile injury can cause a systemic inflammatory response syndrome (SIRS) that resembles the host response during sepsis. The inflammatory response following trauma comprises various systems of the human body which are cross-linked with each other within
Stefanie Hirsiger +4 more
doaj +1 more source
Molecules and Cells, 2015 In the interaction between plants and pathogens, carbon (C) resources provide energy and C skeletons to maintain, among many functions, the plant immune system. However, variations in C availability on pathogen associated molecular pattern (PAMP) triggered immunity (PTI) have not been systematically examined.
Park, Hyeong Cheol +12 more
openaire +3 more sources
Plum pox virus capsid protein suppresses plant pathogen‐associated molecular pattern (PAMP)‐triggered immunity [PDF]
Molecular Plant Pathology, 2016 Summary The perception of pathogen‐associated molecular patterns (PAMPs) by immune receptors launches defence mechanisms referred to as PAMP‐triggered immunity (PTI). Successful pathogens must suppress PTI pathways via the action of effectors to efficiently colonize their hosts. So far, plant PTI has been reported
Nicaise, Valerie, Candresse, Thierry
openaire +4 more sources
The chloride channel family gene CLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity in Arabidopsis [PDF]
Journal of Experimental Botany, 2014 Chloride channel (CLC) family genes are ubiquitous from prokaryotes to eukaryotes and encode proteins with both channel and transporter activities. The Arabidopsis thaliana genome encodes seven CLC genes, and their products are found in a variety of cellular compartments and have various physiological functions.
Guo, Wei +6 more
openaire +2 more sources
Toll-Like Receptors in Liver Fibrosis: cellular crosstalk and mechanisms
Frontiers in Physiology, 2012 Toll-like receptors (TLRs) are pattern recognition receptors that distinguish conserved microbial products, also known as pathogen-associated molecular patterns (PAMPs), from host molecules.
Ling eYang, Ekihiro eSeki
doaj +1 more source