Results 121 to 130 of about 258,381 (291)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceAn RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus [PDF]
, 2013 The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array ...McLellan, Hazel, Petra C Boevink, Beynon Jim L., Gomez, Sonia, Beynon, Jim L., Jim L. Beynon (469129), Boevink Petra C., Beynon, Jim, Whisson, Stephen C., Birch, Paul R. J.; id_orcid, Boevink, Petra, Petra C. Boevink (394247), Pritchard Leighton, Armstrong Miles R., Hazel McLellan, Miles R. Armstrong (469126), Gomez Sonia, Pritchard, Leighton, Juan Morales, Jim L Beynon, Hazel McLellan (469125), Armstrong, Miles, Birch, Paul R. J., Sonia Gomez (469127), Birch Paul R. J., Morales, Juan, Leighton Pritchard, Paul R J Birch, Sonia Gomez, Leighton Pritchard (173498), Stephen C Whisson, McLellan Hazel, Armstrong, Miles R., Paul R. J. Birch (132138), Stephen C. Whisson (110493), Boevink, Petra C., Gómez-Galera, Sonia, Miles R Armstrong, Whisson Stephen C., Morales Juan, Whisson, steve, Juan Morales (469128) +41 morecore +1 more sourceLongitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay +15 morewiley +1 more sourcepathogen-associated molecular pattern
Citation: 'pathogen-associated molecular pattern' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13542 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for ...openaire +1 more sourceGenome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire [PDF]
, 2010 Background: Pythium ultimum (P. ultimum) is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species. Results: The P.Beakes, Gordon W, Lévesque, CA, Cano, L., Puiu, D, Ronald P De Vries, Raffaele, Sylvain, Hostetler, Jessica, Henrissat, B., Paul D Thomas, Phuntmart, Vipaporn, Boore, J.L., Brett R Whitty, Beakes, GW, Whitty, Brett R, Grenville-Briggs, L., Whitty, Brett R., Horner, N, Cano, L, Raffaele, S., Robideau, Gregg P, Steve Ferriera, Tisserat, Ned, Shetty, J, Tisserat, N., Busam, D, Krajaejun, T., Stajich, JE, Holt, C, Yandell, M, Zerillo, MM, C Robin Buell, West, Pieter van, Morris, P., Hamilton, John P, Pedro M Coutinho, Buell, C. Robin, Martin, Frank, Wawra, S, Whitty, B.R., Sucheta Tripathy, Meijer, Harold J. G., Thines, Marco, Buell, C.R., Wawra, Stephan, Win, J, Gregg P Robideau, Gordon W Beakes, Gachon, Claire M. M., Henk Brouwer, Gachon, C.M.M., Ned Tisserat, Susan I Fuerstenberg, Whitty, BR, Busam, Dana, Phuntmart, V., Thomas, P.D., Govers, F, Mark Yandell, Hostetler, J, Marcelo M Zerillo, Gachon, Claire MM, Lévesque, C.A., Neil Horner, Beakes, G.W., Tisserat, N, Dana Busam, Dumas, B., Yandell, M., Horner, Neil, Krajaejun, T, Zerillo, M.M., Joe Win, Edgar Huitema, Tyler, Brett M., Robideau, G.P., Zerillo, M., Zerillo, Marcelo M, Grenville-Briggs, L, Krajaejun, Theerapong, Raffaele, S, Vries, Ronald Peter de, Johnson, J, Theerapong Krajaejun, Coutinho, Pedro, M, Lévesque, C André, Yandell, Mark, Govers, F., Vries, R.P., de, van West, Pieter, Rays HY Jiang, Puiu, Daniela, Boore, JL, Beakes, Gordon W., De Vries, Ronald P., Coutinho, P.M., Gaulin, Elodie, Win, J., Barry Moore, van West, P, Meijer, H.J.G., Meijer, HJG, Lin, H., Wawra, S., Lin, H, Jessica Hostetler, Paul Morris, Lévesque, C. André, Stephan Wawra, Sylvain Raffaele, Laura Grenville-Briggs, Fuerstenberg, S.I., Bernard Dumas, Meijer, Harold JG, Shetty, J., Phuntmart, V, De Vries, R.P., Tripathy, S, Coutinho, Pedro M., Gachon, Claire M M, Moore, B, Thines, M, Claire MM Gachon, Fuerstenberg, SI, Robideau, Gregg P., Henrissat, Bernard, Dumas, B, Huitema, Edgar; id_orcid, Brouwer, Henk, Grenville-Briggs, Laura, Moore, Barry, Hostetler, J., Huitema, E., Liliana Cano, Puiu, D., Coutinho, Pedro,, Hamilton, J.P., Ferriera, Steve, Zerillo, Marcelo M., Marco Thines, Daniela Puiu, Huitema, E, Sophien Kamoun, Henrissat, B, Boore, Jeffrey L., Jiang, Rays HY, Stajich, Jason E, De Vries, Ronald P, Bernard Henrissat, van West, P., Kamoun, Sophien, Gaulin, E, Brouwer, H., Win, Joe, Gaulin, E., West, P., van, Huitema, Edgar, Brouwer, H, Justin Johnson, Jiang, Rays H. Y., Thines, M., Jyoti Shetty, Tripathy, S., Frank Martin, Tyler, Brett M, Buell, C Robin, Jiang, RHY, Buell, CR, Morris, Paul, Govers, Francine, Tyler, B.M., Jason E Stajich, Ferriera, S, Jiang, R.H.Y., John P Hamilton, Martin, F, Meijer, Harold J G, Kamoun, S., Jiang, Rays H Y, Brett M Tyler, Fürstenberg, Susan, Hamilton, John P., Lin, Haining, Horner, N., Elodie Gaulin, Thomas, Paul D, Haining Lin, Robideau, GP, Coutinho, PM, Johnson, Justin, Tyler, BM, Harold JG Meijer, Francine Govers, Fuerstenberg, Susan I, Cano, Liliana, Vipaporn Phuntmart, Stajich, J.E., Moore, B., Holt, Carson, Thomas, Paul D., Holt, C., Hamilton, JP, Gachon, CMM, Shetty, Jyoti, Stajich, Jason E., Carson Holt, Jeffrey L Boore, Coutinho, Pedro M, Martin, F., Boore, Jeffrey L, De Vries, RP, Johnson, J., Pieter van West, Morris, P, Thomas, PD, C André Lévesque, Fuerstenberg, Susan I., Dumas, Bernard, Ferriera, S., Tripathy, Sucheta, Kamoun, S, Busam, D. +220 morecore +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceA new proteinaceous pathogen-associated molecular pattern (PAMP) identified in Ascomycete fungi induces cell death in Solanaceae [PDF]
, 2017 Pathogen-associated molecular patterns (PAMPs) are detected by plant pattern recognition receptors (PRRs), which gives rise to PAMP-triggered immunity (PTI).Kanyuka, K., Kanyuka, Kostya, Adokiye Berepiki, Birch, Paul R. J.; id_orcid, Avrova, Anna, Ruiz, O., Paul R. J. Birch, Gamble, Louise, Griffe, Lucie L., Franco-Orozco, B., Anna Avrova, Gamble, L., Louise Gamble, Shumei Wang, Wang, Shumei, Lucie L. Griffe, Wang, S., Griffe, L. L., Franco-Orozco, Barbara, Ruiz, Olaya, Avrova, A., Berepiki, Adokiye, Berepiki, A., Birch, P. R. J., Olaya Ruiz, Kostya Kanyuka, Barbara Franco‐Orozco +26 morecore +1 more sourceProteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi +10 morewiley +1 more source
