Results 81 to 90 of about 258,381 (291)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Chimeric Pathogen-Associated Molecular Patterns (PAMPs) as Vaccine Adjuvants

Vaccines
The development of pathogen-associated molecular patterns (PAMPs) that signal via pathogen recognition receptors (PRRs) on innate immune cells is a strategy that is widely adopted in adjuvant research.
Bethany M. Potter, Anya F. Weth, Emma M. Dangerfield, Mattie S. M. Timmer, Bridget L. Stocker   +4 more
doaj   +1 more source

ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri [PDF]

The EMBO Reports, 2018
During an infection, the detection of pathogens is mediated through the interactions between pathogen-associated molecular patterns (PAMPs) and pathogen recognition receptors. β-Heptose 1,7-bisphosphate (βHBP), an intermediate of the lipopolysaccharide (LPS) biosynthesis pathway, was recently identified as a bacterial PAMP.
García-Weber, Diego, Dangeard, Anne‐sophie, Cornil, Johan, Thai, Linda, Rytter, Héloïse, Zamyatina, Alla, Mulard, Laurence, Arrieumerlou, Cécile   +7 more
openaire   +2 more sources

Keeping time on the plant-pathogen arms race : a role for the plant circadian clock in immune response [PDF]

, 2011
In this study, Arabidopsis thaliana (Arabidopsis) in the Columbia-0 (Col-0) background showed time-of-day variation in susceptibility to the plant-pathogen Pseudomonas syringae DC3000 pathovar tomato (P.
Bhardwaj, Vaibhav
core  

Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans [PDF]

, 2011
Peer ...
Alistair J. P. Brown, Argo, Evelyn Ann, Michelle D. Leach, MacCallum, Donna Margaret, David A. Stead, Evelyn Argo, Donna M. MacCallum, Stead, David Andrew, Brown, Alistair James Petersen, Leach, Michelle Donna   +9 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Comprehending toll-like receptors: pivotal element in the pathogenesis of sepsis and its complications

Frontiers in Immunology
Sepsis, a critical systemic inflammatory response syndrome elicited by pathogenic microorganisms, poses a significant challenge in clinical practice due to its rapid progression and potential for multi-organ failure.
Wei Wang, Shengtian Mu, Dongli Yan, Huan Qin, Zhen Zheng   +4 more
doaj   +1 more source

Synthesis of glycosyl diglycerides: pathogen-associated molecular patterns [PDF]

, 2015
© 2015 Dr. Mark Bentley RichardsonA total synthesis of a subset of Mycobacterium tuberculosis beta-gentiobiosyl diglyceride natural products is disclosed.
RICHARDSON, MARK
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ADP heptose, a novel pathogen‐associated molecular pattern identified in Helicobacter pylori [PDF]

The FASEB Journal, 2019
ABSTRACT The gastric pathogen Helicobacter pylori activates the NF‐κB pathway in human epithelial cells via the recently discovered α‐kinase 1 TRAF‐interacting protein with forkhead‐associated domain (TIFA) axis.
Pfannkuch, L., Hurwitz, R., Traulsen, J., Sigulla, J., Poeschke, M., Matzner, L., Kosma, P., Schmid, M., Meyer, T.   +8 more
openaire   +3 more sources