Results 81 to 90 of about 256,778 (292)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Frontiers in Immunology, 2018
Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host ...
Tomoya Hayashi, Tomoya Hayashi, Masatoshi Momota, Masatoshi Momota, Etsushi Kuroda, Etsushi Kuroda, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Ken J. Ishii, Hidetoshi Arima, Hidetoshi Arima   +22 more
doaj   +1 more source

Involvement of bacterial TonB-dependent signaling in the generation of an oligogalacturonide damage-associated molecular pattern from plant cell walls exposed to Xanthomonas campestris pv. campestris pectate lyases

, 2012
Vorhölter F-J, Wiggerich H-G, Scheidle H, et al. Involvement of bacterial TonB-dependent signaling in the generation of an oligogalacturonide damage-associated molecular pattern from plant cell walls exposed to Xanthomonas campestris pv.
Vishaldeep Kaur Sidhu, Sidhu Vishaldeep Kaur, Scheidle, Heiko, Küster, Helge, Küster Helge, Wiggerich Heinrich-Günter, Vorhölter, Frank-Jörg, Karsten Niehaus, Mrozek, Kalina, Pühler Alfred, Scheidle Heiko, Vorhölter Frank-Jörg, Alfred Pühler, Sidhu, Vishaldeep Kaur, Frank-Jörg Vorhölter, Heinrich-Günter Wiggerich, Niehaus Karsten, Mrozek Kalina, Niehaus, Karsten, Pühler, Alfred, Pühler, Alfred ; https://orcid.org/, Wiggerich, Heinrich-Günter, Helge Küster, Kalina Mrozek, Heiko Scheidle   +24 more
core   +1 more source

Hierarchy and Roles of Pathogen-Associated Molecular Pattern-Induced Responses in Nicotiana benthamiana     [PDF]

Plant Physiology, 2011
Abstract Our current understanding of pathogen-associated molecular pattern (PAMP)-triggered immunity signaling pathways in plants is limited due to the redundancy of several components or the lethality of mutants in Arabidopsis (Arabidopsis thaliana). To overcome this, we used a virus-induced gene silencing-based approach in combination
Segonzac, Cécile, Feike, Doreen, Gimenez-Ibanez, Selena, Hann, Dagmar R, Zipfel, Cyril, Rathjen, John P   +5 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

ADP-heptose is a pathogen-associated molecular pattern of Shigella flexneri infection [PDF]

, 2018
ABSTRACT During an infection, the detection of pathogens is mediated through interactions between pathogen-associated molecular patterns (PAMPs) and pathogen recognition receptors. β-Heptose 1,7-bisphosphate (βHBP), a metabolite of the lipopolysaccharide (LPS) biosynthesis pathway, was recently identified as a PAMP of
García-Weber, Diego, Dangeard, Anne-Sophie, Cornil, Johan, Thai, Linda, Rytter, Héloise, Mulard, Laurence A., Arrieumerlou, Cécile   +6 more
openaire   +1 more source

ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri [PDF]

EMBO reports, 2018
During an infection, the detection of pathogens is mediated through the interactions between pathogen-associated molecular patterns (PAMPs) and pathogen recognition receptors. β-Heptose 1,7-bisphosphate (βHBP), an intermediate of the lipopolysaccharide (LPS) biosynthesis pathway, was recently identified as a bacterial PAMP.
García-Weber, Diego, Dangeard, Anne‐sophie, Cornil, Johan, Thai, Linda, Rytter, Héloïse, Zamyatina, Alla, Mulard, Laurence, Arrieumerlou, Cécile   +7 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163(T) and comparative genomic insights into plant pathogenicity

, 2010
Smits THM, Jaenicke S, Rezzonico F, et al. Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163(T) and comparative genomic insights into plant pathogenicity. BMC Genomics.
Smits, Theo H. M., Kamber, Tim, Sebastian Jaenicke, Goesmann, Alexander ; https://orcid.org/, Theo HM Smits, Fabio Rezzonico, Rezzonico, Fabio, Jaenicke, Sebastian, Frey, Jürg E, Duffy, Brion, Tim Kamber, Jürg E Frey, Brion Duffy, Alexander Goesmann   +13 more
core   +1 more source

Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models [PDF]

, 2010
We attached the pathogen associated molecular pattern Kdo2-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli.
Tom A. Barr, Juan C. Mareque-Rivas, Gray, David, Barr, Tom A., Martin Krembuszewski, Barr, T.A., Gupta, Manish, Mareque-Rivas, Juan C., Krembuszewski, M., Manish Gupta, Krembuszewski, Martin, Gray, D., David Gray, Mareque-Rivas, J.C., Gupta, M.   +14 more
core   +1 more source