Results 61 to 70 of about 256,778 (292)

Effect of β-Mannanase Addition during Whole Pigs Fattening on Production Yields and Intestinal Health

Animals, 2022
The presence of β-mannans in feed can produce a futile and chronic immune stimulation in fattening pigs. In this trial, a 1-4-endo-D-β-mannanase was added to the feed (HC) during growth and fattening (0.03% of Hemicell HT) and physical performance and ...
Pedro Sánchez-Uribe, Eva Romera-Recio, Carolina G. Cabrera-Gómez, Elisa V. Hernández-Rodríguez, Álvaro Lamrani, Belén González-Guijarro, Clara de Pascual-Monreal, Livia Mendonça-Pascoal, Laura Martínez-Alarcón, Guillermo Ramis   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The role of pathogen-associated molecular patterns and islet-derived danger-associated molecular patterns in longevity of microencapsulated pancreatic islets [PDF]

, 2016
Immunoisolation of cells by encapsulation in semipermeable membranes has been proposed as a cure for many endocrine diseases where a minute-to-minute regulation of metabolites is a requirement such as in anemia, dwarfism, kidney and liver failure ...
Paredes Juárez, Genaro Alberto
core   +3 more sources

PAMPs of Piscirickettsia salmonis Trigger the Transcription of Genes Involved in Nutritional Immunity in a Salmon Macrophage-Like Cell Line

Frontiers in Immunology, 2022
The innate immune system can limit the growth of invading pathogens by depleting micronutrients at a cellular and tissue level. However, it is not known whether nutrient depletion mechanisms discriminate between living pathogens (which require nutrients)
Danixa Pamela Martínez, Danixa Pamela Martínez, Cristian Oliver, Natacha Santibañez, José Leonardo Coronado, Ricardo Oyarzún-Salazar, Ricardo Enriquez, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Alex Romero, Alex Romero   +11 more
doaj   +1 more source

Mycobacterium africanum is associated with patient ethnicity in Ghana [PDF]

, 2014
Mycobacterium africanum is a member of the Mycobacterium tuberculosis complex (MTBC) and an important cause of human tuberculosis in West Africa that is rarely observed elsewhere.
Yeboah-Manu, Dorothy, David Stucki, Otchere, Isaac Darko, Feldmann, Julia, Borrell, Sonia, Dorothy Yeboah-Manu (120059), Gagneux, Sebastien, Jan Hattendorf (113923), Emelia Danso, Adwoa Asante-Poku (335717), Samuel Y. Aboagye, Julia Feldmann (149820), Aboagye, Samuel Y., Stucki, David, Adwoa Asante-Poku, Sebastien Gagneux (149824), Isaac Darko Otchere, Sebastien Gagneux, Sonia Borrell (149821), Isaac Darko Otchere (682528), Julia Feldmann, Emelia Danso (120054), Hattendorf, Jan, Dorothy Yeboah-Manu, Sonia Borrell, David Stucki (149811), Asante-Poku, Adwoa, Samuel Y. Aboagye (567712), Danso, Emelia, Samuel Y Aboagye, Jan Hattendorf   +30 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

Frontiers in Immunology, 2021
EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria.
Kuan-Yu I, Wen-Yi Tseng, Wen-Chih Wang, Siamon Gordon, Siamon Gordon, Kwai-Fong Ng, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin   +8 more
doaj   +1 more source

Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus).

, 2009
(c) 2009 Teacher et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Trenton W J Garner, Richard A. Nichols, Trenton W. J. Garner, Garner, TWJ, Teacher, AGF, Amber G F Teacher, Teacher Amber G. F., Richard A Nichols, Garner Trenton W. J., Amber G. F. Teacher, Nichols, RA, Nichols Richard A.   +11 more
core   +1 more source

The role of BRI1-associated kinase 1 (BAK1) in the regulation of plant innate immunity : functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana [PDF]

, 2014
The role of BRI1-ASSOCIATED KINASE 1 (BAK1) in the regulation of plant innate immunity: functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana SUMMARY BAK1 (BRI1-ASSOCIATED KINASE 1) is an intensively studied member ...
Kiss-Papp, Márta
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source