Results 1 to 10 of about 219,997 (206)
Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification. [PDF]
Int J Mol Sci, 2021 Sepsis is characterized by a dysregulated immune response to infections that causes life-threatening organ dysfunction and even death. When infections occur, bacterial cell wall components (endotoxin or lipopolysaccharide), known as pathogen-associated molecular patterns, bind to pattern recognition receptors, such as toll-like receptors, to initiate ...
Moriyama K, Nishida O.
europepmc +4 more sources
Helicobacter pylori Pathogen-Associated Molecular Patterns: Friends or Foes? [PDF]
Int J Mol Sci, 2022 Microbial infections are sensed by the host immune system by recognizing signature molecules called Pathogen-Associated Molecular Patterns—PAMPs. The binding of these biomolecules to innate immune receptors, called Pattern Recognition Receptors (PRRs), alerts the host cell, activating microbicidal and pro-inflammatory responses.
Eletto D +5 more
europepmc +4 more sources
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. [PDF]
Nat Commun, 2022 AbstractThe formyl peptide receptor 1 (FPR1) is primarily responsible for detection of short peptides bearing N-formylated methionine (fMet) that are characteristic of protein synthesis in bacteria and mitochondria. As a result, FPR1 is critical to phagocyte migration and activation in bacterial infection, tissue injury and inflammation.
Chen G +14 more
europepmc +4 more sources
Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. [PDF]
Crit Care Med, 2013 Bidirectional links between the nervous and immune systems modulate inflammation. The cellular mechanisms underlying the detection of danger-associated molecular patterns and pathogen-associated molecular patterns by the nervous system are not well understood.
Ackland GL +4 more
europepmc +6 more sources
Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes. [PDF]
PLoS One, 2017 Circadian rhythms are endogenous 24-h oscillations that influence a multitude of physiological processes. The pathogen-associated molecular pattern (PAMP), lipopolysaccharide, has been shown to modify the circadian molecular clock. The aim of this study was to determine if other PAMPs alter clock gene expression.
Silver AC.
europepmc +5 more sources
Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines [PDF]
Trends in Biotechnology, 2011 Vaccine development has progressed significantly and has moved from whole microorganisms to subunit vaccines that contain only their antigenic proteins. Subunit vaccines are often less immunogenic than whole pathogens; therefore, adjuvants must amplify the immune response, ideally establishing both innate and adaptive immunity.
Fiona A Sharp, Tarek M Fahmy
exaly +3 more sources
The Effects of Pathogen-Associated Molecular Patterns on Peripheral Blood Monocytes in Patients with Non-alcoholic Fatty Liver Disease. [PDF]
J Clin Exp Hepatol, 2022 Li Q, Rempel JD, Yang J, Minuk GY.
europepmc +2 more sources
COPD disease severity and innate immune response to pathogen-associated molecular patterns. [PDF]
Int J Chron Obstruct Pulmon Dis, 2016 The airways of COPD patients are often colonized with bacteria leading to increased airway inflammation. This study sought to determine whether systemic cytokine responses to microbial pathogen-associated molecular patterns (PAMPs) are increased among subjects with severe COPD.
Fan VS, Gharib SA, Martin TR, Wurfel MM.
europepmc +5 more sources
Scientific ReportsAbstractDamage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) are key triggers of inflammation in sepsis. However, they have rarely been studied simultaneously. Thus, in the present study of patients with bacteraemic infection, we aimed to study how DAMP dynamics are linked to disease severity and outcome and ...
Íngrid Ziegler +2 more
exaly +4 more sources
Poultry Science, 2007 Various potential immune-modulating microbially derived pathogen-associated molecular patterns (PAMP), or so called homotopes, are present in high concentrations in the environment of food animals. In previous studies, intravenously administered PAMP had variable effects on specific primary and secondary immune responses of poultry to systemically ...
G De Vries Reilingh +2 more
exaly +4 more sources