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Evolutionary trajectory of pattern recognition receptors in plants [PDF]
Nature Communications, 2023 Cell-surface receptors play pivotal roles in many biological processes, including immunity, development, and reproduction, across diverse organisms. How cell-surface receptors evolve to become specialised in different biological processes remains elusive.
Bruno Pok Man Ngou +4 more
doaj +5 more sources
Pattern recognition receptors in health and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged senescent cells.
Danyang Li, Minghua Wu
doaj +6 more sources
Immune functions of pattern recognition receptors in Lepidoptera [PDF]
Frontiers in Immunology, 2023 Pattern recognition receptors (PRRs), as the “sensors” in the immune response, play a prominent role in recognizing pathogen-associated molecular patterns (PAMPs) and initiating an effective defense response to pathogens in Lepidoptera.
Lin Zhao +4 more
doaj +3 more sources
Role of pattern recognition receptors in sensing Mycobacterium tuberculosis [PDF]
Heliyon, 2023 Mycobacterium tuberculosis is one of the major invasive intracellular pathogens causing most deaths by a single infectious agent. The interaction between host immune cells and this pathogen is the focal point of the disease, Tuberculosis.
S.M. Neamul Kabir Zihad +7 more
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Pattern recognition receptors: function, regulation and therapeutic potential [PDF]
Signal Transduction and Targeted TherapyPattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Ruochan Chen +5 more
doaj +3 more sources
cGLRs are a diverse family of pattern recognition receptors in innate immunity [PDF]
Cell, 2023 Summary cGAS (cyclic GMP-AMP synthase) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2′3′-cGAMP that activates STING-dependent downstream immunity.
Philip J Kranzusch
exaly +3 more sources
Inhibitory pattern recognition receptors. [PDF]
J Exp Med, 2022 Pattern recognition receptors (PRRs) activate immune cells upon sensing microbes or tissue damage. To prevent immunopathology, these patterns should not always lead to activation.
Rumpret M +3 more
europepmc +4 more sources
Anti-Viral Pattern Recognition Receptors as Therapeutic Targets
Cells, 2021 Pattern recognition receptors (PRRs) play a central role in the inflammation that ensues following microbial infection by their recognition of molecular patterns present in invading microorganisms but also following tissue damage by recognising molecules
Conor Hennessy, Declan P. McKernan
doaj +2 more sources
Pattern-recognition receptors in endometriosis: A narrative review [PDF]
Frontiers in Immunology, 2023 Endometriosis is closely associated with ectopic focal inflammation and immunosuppressive microenvironment. Multiple types of pattern recognition receptors (PRRs) are present in the innate immune system, which are able to detect pathogen-associated ...
Bao Guo +7 more
doaj +2 more sources
Pattern recognition receptors and inflammasome: Now and beyond [PDF]
Molecules and Cells: Pattern recognition receptors (PRRs) are fundamental to the innate immune system, functioning to detect and eliminate invading pathogens by inhibiting their replication and limiting host tissue damage.
SuHyeon Oh, Young Ki Choi, SangJoon Lee
doaj +2 more sources