Results 221 to 230 of about 639,618 (274)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

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Pattern recognition receptors in annelids.

Developmental & Comparative Immunology, 2019
The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as ...
P. Procházková, R. Roubalova, J. Dvorak, N. I. Navarro Pacheco, M. Bilej   +4 more
semanticscholar   +3 more sources

Context-dependent functions of pattern recognition receptors in cancer

Nature Reviews Cancer, 2022
Si Ming Man, Brendan Jenkins, Man Si Ming   +2 more
exaly   +2 more sources

Pattern recognition receptors

Avian Immunology, 2022
Adrian L. Smith, Steven R. Fiddaman
semanticscholar   +2 more sources

Plant pattern-recognition receptors.

Trends in Immunology, 2014
Plants are constantly exposed to would-be pathogens in their immediate environment. Yet, despite relying on innate immunity only, plants are resistant to most microbes. They employ pattern-recognition receptors (PRRs) for sensitive and rapid detection of the potential danger caused by microbes and pests. Plant PRRs are either surface-localized receptor
C. Zipfel
semanticscholar   +5 more sources

Pattern recognition receptors in the crustacean immune response against bacterial infections

, 2021
Bacterial infections represent a high risk in crustacean production and have a highly negative impact, generating important economic losses around the world.
J. Sánchez-Salgado, M. A. Pereyra, J. Alpuche-Osorno, E. Zenteno   +3 more
semanticscholar   +1 more source

Targeting pattern-recognition receptors to discover new small molecule immune modulators

European Journal of Medicinal Chemistry, 2018
Shuwen Liu, Kutty Selva Nandakumar, Kui Cheng   +2 more
exaly   +2 more sources

Pattern recognition receptors: an update

Expert Review of Clinical Immunology, 2006
The vertebrate immune system consists of two inter-related components, the innate and adaptive responses, which are required for the resolution of infection. The innate immune response is critical for the immediate protection from infection and for marshalling the B- and T-cell responses of the adaptive response.
Goutagny, Nadege, Fitzgerald, Katherine A   +1 more
openaire   +3 more sources

CD14 Is a pattern recognition receptor

Immunity, 1994
Septic shock caused by a diverse group of bacterial pathogens is a serious human disease. Recognition of bacterial envelope constituents is one mechanism used by mammalian cells to initiate responses leading to bacterial killing or, unfortunately, responses that also cause fatal septic shock.
J, Pugin, I D, Heumann, A, Tomasz, V V, Kravchenko, Y, Akamatsu, M, Nishijima, M P, Glauser, P S, Tobias, R J, Ulevitch   +8 more
openaire   +2 more sources