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Pattern Recognition Receptors and Liver Failure
Critical Reviews in Immunology, 2019Liver failure is a clinical syndrome with many causes, a complicated pathogenesis, diverse clinical manifestations, and very high mortality. No effective treatment is yet available. Main pathological processes of liver failure include direct damage to parenchymal and nonparenchymal liver cells that might be caused by viruses or drugs, immune-mediated ...
Wu, Jun +7 more
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Pattern-recognition Receptors in Pulp Defense
Advances in Dental Research, 2011Initial sensing of infection is mediated by germline-encoded pattern-recognition receptors (PRRs), the activation of which leads to the expression of inflammatory mediators responsible for the elimination of pathogens and infected cells. PRRs act as immune sensors that provide immediate cell responses to pathogen invasion or tissue injury.
Florence Carrouel +2 more
exaly +3 more sources
Pattern recognition receptors as potential drug targets in inflammatory disorders.
Advances in Protein Chemistry and Structural Biology, 2020Pattern recognition receptors (PRRs) are a key part of the innate immune system, the body's first line of defense against infection and tissue damage. This superfamily of receptors including Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type ...
D. McKernan
semanticscholar +1 more source
Visualising pattern recognition receptor signalling
Biochemical Society Transactions, 2017Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease.
Charlotte, Macleod, Clare E, Bryant
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Pattern recognition receptors in Drosophila immune responses.
Developmental and Comparative Immunology, 2019Insects, which lack the adaptive immune system, have developed sophisticated innate immune system consisting of humoral and cellular immune responses to defend against invading microorganisms.
Yuzhen Lu +7 more
semanticscholar +1 more source
Plant Pattern Recognition Receptors
Methods in Molecular Biology, 2017Libo Shan, P. He
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Current Opinion in Insect Science, 2019
Through evolution, selection pressures cause both insects and the pathogens attacking them to adapt so that they will both survive and this has been called the co-evolutionary 'arms race'. Insects expand their repertoire of pattern recognition receptors (
Xialu Wang +3 more
semanticscholar +1 more source
Through evolution, selection pressures cause both insects and the pathogens attacking them to adapt so that they will both survive and this has been called the co-evolutionary 'arms race'. Insects expand their repertoire of pattern recognition receptors (
Xialu Wang +3 more
semanticscholar +1 more source
Identification and functions of pattern-recognition receptors
Journal of Allergy and Clinical Immunology, 2010Since the identification of Toll-like receptors, our knowledge about pattern-recognition receptors (PRRs) has increased rapidly. Classes of PRRs that have been recently discovered include RIG-I-like receptors, Nod-like receptors, and C-type lectin receptors.
Yutaro, Kumagai, Shizuo, Akira
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Expression of pattern recognition receptors in cholesteatoma
European Archives of Oto-Rhino-Laryngology, 2013Although many immunologic mechanisms have been investigated in studies of the pathogenesis of cholesteatoma, the role of pattern recognition receptors (PRRs) has not been fully determined. Therefore, we assessed innate immune responses in patients with cholesteatoma. We prospectively evaluated 21 patients with acquired cholesteatoma between August 2010
Ho Yun, Lee +4 more
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Pattern recognition receptor function in neutrophils
Trends in Immunology, 2013Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine ...
Thomas, Christina J., Schroder, Kate
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