Results 71 to 80 of about 689,097 (325)

Receptor-like kinases and pathogen-associated molecular patterns perception in Arabidopsis [PDF]

, 2006
Comparable to the innate immune response in mammals and insects, plants possess highly specific and sensitive recognition systems for pathogen-associated molecular patterns (PAMPs), such as bacterial flagellin.
Zipfel, Cyril
core   +1 more source

Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62 [PDF]

, 2011
ES-62 is an immunomodulatory phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae. Previously, the use of knockout mice has revealed the effects of ES-62 on macrophages and dendritic cells to be
Goodridge, H.S., Helen S. Goodridge, Harnett, W., Janet M. Allen, Allen, Janet, Harnett, Margaret, Allen, J.M., Goodridge, Helen, Harnett, M., Harnett, William, Margaret Harnett, William Harnett   +11 more
core   +1 more source

Heterogeneity in Fibroblast Proliferation and Survival in Idiopathic Pulmonary Fibrosis

Frontiers in Pharmacology, 2014
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling ...
David Michael Habiel, Cory eHogaboam
doaj   +1 more source

CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo

, 2007
Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus, Koch, Alexander, Schwederski, Markus, Ehrentraut Heidi, Baumgarten, Georg, Ehrentraut, Heidi, Hoeft, Andreas, Velten, Markus, Knüfermann, Pascal, Zacharowski Kai, Hoeft Andreas, Mersmann Jan, Knuefermann Pascal, Meyer Rainer, Grohé Christian, Baumgarten Georg, Zacharowski, Kai, Koch Alexander, Meyer, Rainer, Grohé, Christian, Velten Markus, Mersmann, Jan   +21 more
core   +1 more source

Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein [PDF]

, 1992
Computer simulation of the conformations of short antigenic peptides (&lo residues) either free or bound to their receptor, the major histocompatibility complex (MHC)- encoded glycoprotein H-2 Ld, was employed to explain experimentally determined ...
Reddehase, Matthias J., Rognan, Didier, Koszinowski, Ulrich H., Folkers, Gerd, Gerd Folkers, Didier Rognan, Matthias J. Reddehase, Ulrich H. Koszinowski   +7 more
core   +1 more source

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Nature Communications, 2018
TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal ...
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak   +19 more
doaj   +1 more source

EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans

Nature Microbiology, 2017
Oral epithelial cells discriminate between pathogenic and non-pathogenic stimuli, and only induce an inflammatory response when they are exposed to high levels of a potentially harmful microorganism. The pattern recognition receptors (PRRs) in epithelial
M. Swidergall, N. Solis, M. Lionakis, S. Filler   +3 more
semanticscholar   +1 more source

Recognition of Pep-13/25 MAMPs of Phytophthora localizes to an RLK locus in Solanum microdontum

Frontiers in Plant Science, 2023
Pattern-triggered immunity (PTI) in plants is mediated by cell surface-localized pattern recognition receptors (PRRs) upon perception of microbe-associated molecular pattern (MAMPs). MAMPs are conserved molecules across microbe species, or even kingdoms,
Xiao Lin, Yerisf Carla Torres Ascurra, Happyka Fillianti, Laura Dethier, Laura de Rond, Emmanouil Domazakis, Carolina Aguilera-Galvez, Afewerki Yohannes Kiros, Evert Jacobsen, Richard G. F. Visser, Thorsten Nürnberger, Thorsten Nürnberger, Vivianne G. A. A. Vleeshouwers   +12 more
doaj   +1 more source

SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity

Nature Communications, 2018
Detection of conserved microbial patterns by host cell surface pattern recognition receptors (PRRs) activates innate immunity. The FLAGELLIN-SENSITIVE 2 (FLS2) receptor perceives bacterial flagellin and recruits another PRR, BAK1 and the cytoplasmic ...
Beatriz Orosa, Gary Yates, Vivek Verma, A. Srivastava, Moumita Srivastava, Alberto Campanaro, D. De Vega, Alanna Fernandes, Cunjin Zhang, Jack Lee, M. Bennett, A. Sadanandom   +11 more
semanticscholar   +1 more source

Lectin receptor kinases in plant innate immunity

Frontiers in Plant Science, 2013
A key feature of innate immunity is the ability to recognize and respond to potential pathogens in a highly sensitive and specific manner. In plants, the first layer of defense is induced after recognition by pattern recognition receptors of microbe ...
Prashant eSingh, Laurent eZimmerli
doaj   +1 more source