Results 61 to 70 of about 689,097 (325)

Intracellular pattern-recognition receptors☆

Advanced Drug Delivery Reviews, 2008
The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in detail.
DOSTERT, C, Meylan, Etienne, Tschopp, J
openaire   +4 more sources

Pattern recognitions receptors in immunodeficiency disorders [PDF]

European Journal of Pharmacology, 2017
Pattern recognition receptors (PRRs) recognize common microbial or host-derived macromolecules and have important roles in early activation and response of the immune system. Initiation of the innate immune response starts with the recognition of microbial structures called pathogen associated molecular patterns (PAMPs).
Mortaz, E, Adcock, IM, Tabarsi, P, Darazam, IA, Movassaghi, M, Garssen, J, Jamaati, H, Velayati, A   +7 more
openaire   +4 more sources

Primary immunodeficiencies of pattern recognition receptors [PDF]

Journal of Internal Medicine, 2012
AbstractPrimary immunodeficiencies (PIDs) are severe defects in the capacity of the host to mount a proper immune response, and are characterized by an increased susceptibility to infections. Although classical immunodeficiencies have been characterized based on broad defects in cell populations (e.g.
Netea, M.G., van de Veerdonk, F.L., Meer, J.W.M. van der   +2 more
openaire   +3 more sources

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

PLoS Pathogens, 2008
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus ...
Sigrid E M Heinsbroek, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, Siamon Gordon   +5 more
doaj   +1 more source

Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

Cell, 2017
SUMMARY Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses.
B. Nabet, Yu Qiu, J. Shabason, Tony J. Wu, T. Yoon, Brian Kim, Joseph L. Benci, A. DeMichele, J. Tchou, J. Marcotrigiano, A. Minn   +10 more
semanticscholar   +1 more source

Pattern‐recognition receptors in human eosinophils [PDF]

Immunology, 2012
SummaryThe pattern‐recognition receptor (PRR) family includes Toll‐like receptors (TLRs), nucleotide‐binding oligomerization domain (NOD) ‐like receptors (NLRs), RIG‐I‐like receptors (RLRs), C‐type lectin receptors (CLRs) and the receptor for advanced glycation end products (RAGE).
Anne Månsson, Kvarnhammar, Lars Olaf, Cardell   +1 more
openaire   +2 more sources

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1

Cell Reports, 2015
RIPK1 and RIPK3, two closely related RIPK family members, have emerged as important regulators of pathologic cell death and inflammation. In the current work, we report that the Bcr-Abl inhibitor and anti-leukemia agent ponatinib is also a first-in-class
Malek Najjar, Chalada Suebsuwong, Soumya S. Ray, Roshan J. Thapa, Jenny L. Maki, Shoko Nogusa, Saumil Shah, Danish Saleh, Peter J. Gough, John Bertin, Junying Yuan, Siddharth Balachandran, Gregory D. Cuny, Alexei Degterev   +13 more
doaj   +1 more source

Mini-Review: Bioactivities of Bacterial Cell Envelopes in the Central Nervous System

Frontiers in Cellular and Infection Microbiology, 2020
During acute bacterial meningitis, recognition of the bacterial envelope by immune cells of the central nervous system (CNS) generates a robust response that is essential to clear bacteria.
William J. MacCain, Elaine I. Tuomanen
doaj   +1 more source

Virus sensing receptors in cellular infectivity of influenza A virus

Journal of Infection in Developing Countries, 2021
An innate immune response is essential to mobilize protective immunity upon the infection of respiratory epithelial cells with influenza A virus (IAV).
Shaihana Almatrrouk, Iram Saba, Suhair Abozaid, Ahmed A Al-Qahtani, Mohammed N Al-Ahdal   +4 more
doaj   +1 more source

Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

Mediators of Inflammation, 2019
Obesity-induced chronic inflammation is known to promote the development of many metabolic diseases, especially insulin resistance, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerosis.
Lili Yu, Yanhua Li, Cancan Du, Weidong Zhao, Hanxiao Zhang, Yun Yang, Aiping Sun, Xiangfeng Song, Zhiwei Feng   +8 more
semanticscholar   +1 more source