Results 41 to 50 of about 689,097 (325)
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background and aims: C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI).
Hai-Yun Li +9 more
doaj +1 more source
The innate immune receptor Nlrp12 suppresses autoimmunity to the retina
Journal of Neuroinflammation, 2022 Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined.
Ellen J. Lee +6 more
doaj +1 more source
Cells, 2021 Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy.
Yulin Ouyang +13 more
doaj +1 more source
Pattern Recognition Receptors in HIV Transmission [PDF]
Frontiers in Immunology, 2012 Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection. These innate cells play distinct roles in initiation of HIV-1 infection and induction of anti-viral immunity. DCs are potent migratory cells that capture HIV-1 and transfer virus to
Mesman, Annelies W. +1 more
openaire +3 more sources
Serum Amyloid A is a Soluble Pattern Recognition Receptor that Drives Type 2 Immunity
Nature Immunology, 2020 The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an ...
U. Smole +18 more
semanticscholar +1 more source
Pattern-Recognition Receptors and Gastric Cancer [PDF]
Frontiers in Immunology, 2014 Chronic inflammation has been associated with an increased risk of several human malignancies, a classic example being gastric adenocarcinoma (GC). Development of GC is known to result from infection of the gastric mucosa by Helicobacter pylori, which initially induces acute inflammation and, in a subset of patients, progresses over time to chronic ...
Castaño-Rodríguez, N +2 more
openaire +4 more sources
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2
eLife, 2022 C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji +12 more
doaj +1 more source
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Cell Reports, 2014 Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger +15 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2016 Sensing of potential pathogenic bacteria is of critical importance for immunity. In plants, this involves plasma membrane-resident pattern recognition receptors, one of which is the FLAGELLIN SENSING 2 (FLS2) receptor kinase.
Malick Mbengue +10 more
semanticscholar +2 more sources
Pattern recognition receptors in health and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 AbstractPattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged senescent cells. PRRs bridge nonspecific immunity and specific immunity.
Danyang Li, Minghua Wu
openaire +3 more sources