Results 41 to 50 of about 246,063 (155)
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Nature Communications, 2018 TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal ...
Lucia Taraborrelli +19 more
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Heterogeneity in Fibroblast Proliferation and Survival in Idiopathic Pulmonary Fibrosis
Frontiers in Pharmacology, 2014 Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling ...
David Michael Habiel, Cory eHogaboam
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Recognition of Pep-13/25 MAMPs of Phytophthora localizes to an RLK locus in Solanum microdontum
Frontiers in Plant Science, 2023 Pattern-triggered immunity (PTI) in plants is mediated by cell surface-localized pattern recognition receptors (PRRs) upon perception of microbe-associated molecular pattern (MAMPs). MAMPs are conserved molecules across microbe species, or even kingdoms,
Xiao Lin +12 more
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Plant pattern-recognition receptors
Trends in Immunology, 2014 Plants are constantly exposed to would-be pathogens in their immediate environment. Yet, despite relying on innate immunity only, plants are resistant to most microbes. They employ pattern-recognition receptors (PRRs) for sensitive and rapid detection of the potential danger caused by microbes and pests. Plant PRRs are either surface-localized receptor
openaire +4 more sources
Molecular Plant-Microbe Interactions, 2023 Plants rely on innate immune systems to defend against a wide variety of biotic attackers. Key components of innate immunity include cell-surface pattern-recognition receptors (PRRs), which recognize pest- and pathogen-associated molecular patterns ...
Anthony G. K. Garcia +1 more
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Pattern recognition receptors in antifungal immunity [PDF]
Seminars in Immunopathology, 2014 Receptors of the innate immune system are the first line of defence against infection, being able to recognise and initiate an inflammatory response to invading microorganisms. The Toll-like (TLR), NOD-like (NLR), RIG-I-like (RLR) and C-type lectin-like receptors (CLR) are four receptor families that contribute to the recognition of a vast range of ...
Plato, Anthony +2 more
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Lectin receptor kinases in plant innate immunity
Frontiers in Plant Science, 2013 A key feature of innate immunity is the ability to recognize and respond to potential pathogens in a highly sensitive and specific manner. In plants, the first layer of defense is induced after recognition by pattern recognition receptors of microbe ...
Prashant eSingh, Laurent eZimmerli
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Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis
Protein & Cell, 2020 While emerging data suggest nucleotide oligomerization domain receptor 1 (NOD1), a cytoplasmic pattern recognition receptor, may play an important and complementary role in the immune response to bacterial infection, its role in cancer metastasis is ...
Henry Y. Jiang +18 more
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Evolutionary trajectory of pattern recognition receptors in plants
Nature Communications, 2023 Abstract Cell-surface receptors play pivotal roles in many biological processes, including immunity, development, and reproduction, across diverse organisms. How cell-surface receptors evolve to become specialised in different biological processes remains elusive.
Bruno Pok Man Ngou +4 more
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Frontiers in Immunology, 2017 DM9 domain was first identified in Drosophila melanogaster, and it was subsequently found to integrate with or without other protein domains across a wide range of invertebrates and vertebrates.
Shuai Jiang +13 more
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