Results 31 to 40 of about 689,097 (325)
Cnidarian Pattern Recognition Receptor Repertoires Reflect Both Phylogeny and Life History Traits [PDF]
Frontiers in Immunology, 2021 Pattern recognition receptors (PRRs) are evolutionarily ancient and crucial components of innate immunity, recognizing danger-associated molecular patterns (DAMPs) and activating host defenses.
Madison A. Emery +2 more
doaj +2 more sources
Human TLR10 is an anti-inflammatory pattern-recognition receptor
Proceedings of the National Academy of Sciences of the United States of America, 2014 Significance We demonstrate the biological role of TLR10, the only member of the Toll-like receptor (TLR)-family so far without a known function. We show that TLR10 acts as an inhibitory receptor, with suppressive effects.
M. Oosting +15 more
semanticscholar +2 more sources
Pattern recognition receptor function in neutrophils
Trends in Immunology, 2013 Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine ...
Thomas, Christina J., Schroder, Kate
openaire +6 more sources
The Arabidopsis pattern recognition receptor EFR enhances fire blight resistance in apple. [PDF]
Hortic Res, 2021 Fire blight disease, caused by the bacterium Erwinia amylovora (E. amylovora), is responsible for substantial losses in cultivated apples worldwide. An important mechanism of plant immunity is based on the recognition of conserved microbial molecules ...
Piazza S +7 more
europepmc +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Toll/Toll-like receptors are key regulators of the innate immune system in both invertebrates and vertebrates. However, while mammalian Toll-like receptors function as pattern recognition receptors that directly bind microbe-associated ...
Ruonan Zhang +13 more
semanticscholar +1 more source
Pattern Recognition Receptors and Autophagy [PDF]
Frontiers in Immunology, 2014 The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control immune responses.
Oh, JE Oh, Ji Eun +1 more
openaire +4 more sources
Identifying the Patterns of Pattern Recognition Receptors [PDF]
Immunity, 2018 Intestinal homeostasis requires microbial recognition that results in appropriate responses to commensals and pathogens. In this issue of Immunity, Price et al. (2018) map the in vivo expression of five toll-like receptors (TLR) in intestinal epithelia, revealing distinct spatio-temporal expression patterns that shape responses to TLR ligands.
Andrea A, Hill, Gretchen E, Diehl
openaire +2 more sources
Inhibitory pattern recognition receptors
Journal of Experimental Medicine, 2021 Pathogen- and damage-associated molecular patterns are sensed by the immune system’s pattern recognition receptors (PRRs) upon contact with a microbe or damaged tissue. In situations such as contact with commensals or during physiological cell death, the immune system should not respond to these patterns.
Matevž Rumpret +3 more
openaire +2 more sources
Japanese Journal of Clinical Immunology, 2011 Immunity is based on self/nonself discrimination. In vertebrates, two major systems, innate and adaptive immune systems, constitute host defense against invading microbes. Adaptive immunity is characterized by specific immune responses through B- or T-cell antigen receptors that are generated by somatic recombination, whereas nonspecific responses to ...
Takaya, Hayashi +2 more
openaire +4 more sources
Pattern Recognition Receptors and Inflammation [PDF]
Cell, 2010 Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors.
Takeuchi, Osamu, Akira, Shizuo
openaire +2 more sources