Genotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1 [PDF]
Nature Communications, 2022 Pattern-triggered immunity is activated by recognition of microbe-derived structures by host pattern recognition receptors. Here the authors use a genotype-by sequencing approach to show that bacterial translation initiation factor 1 triggers PTI in ...
Li Fan +15 more
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Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions. Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and damage-associate molecular patterns (DAMPs) that are agonists for innate immune ...
Guang Han Ong +3 more
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LYSMD3: A mammalian pattern recognition receptor for chitin. [PDF]
Cell Rep, 2021 SUMMARY Chitin, a major component of fungal cell walls, has been associated with allergic disorders such as asthma. However, it is unclear how mammals recognize chitin and the principal receptor(s) on epithelial cells that sense chitin remain to be ...
He X +18 more
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RIG-I: a multifunctional protein beyond a pattern recognition receptor
Protein & Cell, 2017 It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs.
Xiao-xiao Xu +5 more
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The activating receptor NKG2D is an anti-fungal pattern recognition receptor [PDF]
Nature CommunicationsNKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8+ T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous
Yoav Charpak-Amikam +11 more
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Frontiers in Immunology, 2017 DM9 domain was first identified in Drosophila melanogaster, and it was subsequently found to integrate with or without other protein domains across a wide range of invertebrates and vertebrates.
Shuai Jiang +13 more
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NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages. [PDF]
Sci Immunol, 2023 Endotoxin—bacterial lipopolysaccharide (LPS)—is a driver of lethal infection sepsis through excessive activation of innate immune responses. When delivered to the cytosol of macrophages, cytosolic LPS (cLPS) induces the assembly of an inflammasome that ...
Rojas-Lopez M +8 more
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Avian Pattern Recognition Receptor Sensing and Signaling
Veterinary Sciences, 2020 Pattern recognition receptors (PRRs) are a class of immune sensors that play a critical role in detecting and responding to several conserved patterns of microorganisms.
Sabari Nath Neerukonda, Upendra Katneni
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Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition [PDF]
eLife, 2022 As a first step in innate immunity, pattern recognition receptors (PRRs) recognize the distinct pathogen and herbivore-associated molecular patterns and mediate activation of immune responses, but specific steps in the evolution of new PRR sensing ...
Simon Snoeck +5 more
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Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease. [PDF]
Gastroenterology, 2022 Inflammatory bowel disease (IBD) is characterized by defects in epithelial function and dysregulated inflammatory signaling by lamina propria mononuclear cells including macrophages and dendritic cells in response to microbiota.
Abraham C, Abreu MT, Turner JR.
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