Pattern recognition receptor ligand-induced differentiation of human transitional B cells. [PDF]
PLoS ONE, 2022 B cells represent a critical component of the adaptive immune response whose development and differentiation are determined by antigen-dependent and antigen-independent interactions.
Jourdan K P McMillan +2 more
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Regulation of pattern recognition receptor signaling by palmitoylation [PDF]
iScienceSummary: Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological ...
Xiaocui Li +5 more
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Pattern recognition receptor signaling and innate immune responses to schistosome infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Schistosomiasis remains to be a significant public health problem in tropical and subtropical regions. Despite remarkable progress that has been made in the control of the disease over the past decades, its elimination remains a daunting challenge in ...
Nouhoum Dibo +6 more
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Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis
Protein & Cell, 2020 While emerging data suggest nucleotide oligomerization domain receptor 1 (NOD1), a cytoplasmic pattern recognition receptor, may play an important and complementary role in the immune response to bacterial infection, its role in cancer metastasis is ...
Henry Y. Jiang +18 more
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Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Cancer immunotherapies are generally effective in patients whose tumors contain a priori primed T-cells reactive to tumor antigens (TA).
Michael Yellin +13 more
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The Emerging Roles of Pellino Family in Pattern Recognition Receptor Signaling [PDF]
Frontiers in Immunology, 2022 The Pellino family is a novel and well-conserved E3 ubiquitin ligase family and consists of Pellino1, Pellino2, and Pellino3. Each family member exhibits a highly conserved structure providing ubiquitin ligase activity without abrogating cell and ...
E Zhang, Xia Li, Xia Li
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Dynamin-Related Proteins Enhance Tomato Immunity by Mediating Pattern Recognition Receptor Trafficking [PDF]
Membranes, 2022 Pattern recognition receptor (PRR) trafficking to the plasma membrane and endocytosis plays a crucial role in pattern triggered immunity (PTI). Dynamin-related proteins (DRPs) participate in endocytosis and recycling.
Meirav Leibman-Markus +5 more
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Inflammasome-Associated Gastric Tumorigenesis Is Independent of the NLRP3 Pattern Recognition Receptor [PDF]
Frontiers in Oncology, 2022 Inflammasomes are important multiprotein regulatory complexes of innate immunity and have recently emerged as playing divergent roles in numerous inflammation-associated cancers.
Alice J. West +12 more
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Pattern recognition receptor signaling in otitis media: immune crosstalk and pathogenic mechanisms [PDF]
Frontiers in ImmunologyOtitis media (OM) remains a prevalent and multifactorial inflammatory disease of the middle ear, especially in pediatric populations. The immune system, particularly pattern recognition receptors (PRRs), plays a central role in detecting microbial ...
Mingwen Guo +5 more
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Plant pattern-recognition receptors
Trends in Immunology, 2014 Plants are constantly exposed to would-be pathogens in their immediate environment. Yet, despite relying on innate immunity only, plants are resistant to most microbes. They employ pattern-recognition receptors (PRRs) for sensitive and rapid detection of the potential danger caused by microbes and pests. Plant PRRs are either surface-localized receptor
Zipfel, Cyril
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