Results 41 to 50 of about 401,379 (287)

Pattern recognitions receptors in immunodeficiency disorders [PDF]

European Journal of Pharmacology, 2017
Pattern recognition receptors (PRRs) recognize common microbial or host-derived macromolecules and have important roles in early activation and response of the immune system. Initiation of the innate immune response starts with the recognition of microbial structures called pathogen associated molecular patterns (PAMPs).
Mortaz, E, Adcock, IM, Tabarsi, P, Darazam, IA, Movassaghi, M, Garssen, J, Jamaati, H, Velayati, A   +7 more
openaire   +4 more sources

Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis. [PDF]

, 2015
Tuberculosis (TB) is considered a major worldwide health problem with 10 million new cases diagnosed each year. Our understanding of TB immunology has become greater and more refined since the identification of Mycobacterium tuberculosis (MTB) as an ...
A Aderem, A Azzurri, A Bafica, A Kumar, A Mantovani, AB Kamath, AC Ogus, AG Bean, Ali Akbar Velayati, B Abel, B Albiger, B Bottazzi, BB Mishra, BE Schneider, C Garlanda, C Garlanda, C Nathan, C Picard, CA Dinarello, CA Scanga, CC Khor, CH Ladel, CM Fremond, CM Fremond, D Biswas, D Castaño, D Kebir El, Davood Mansouri, DG Souza, DM Underhill, DR Andrade Jr, DR Velez, E Giacomini, E Kay, E Lorenz, E Meylan, E Mortaz, E Torrado, EA Kurt-Jones, EK Jo, Esmaeil Mortaz, F Breviario, F Martinon, G Courtois, G Fenhalls, GA Rook, GW Lee, GW Lee, GY Chen, H Hemmi, H Kumar, H Kumar, H Yamada, HM Lee, I Sugawara, Ian M. Adcock, IC Koo, J Branger, J Bustamante, J Chan, J Kleinnijenhuis, J Kleinnijenhuis, J Kluijver de, J Zuñiga, JC Mak, Jean-Laurent Casanova, JJ Yim, JL Casanova, JP Ting, JS Beckman, K Happel, K Takeda, KD Mayer-Barber, L Alexopoulou, L Gan, L Pompei, LA Pinxteren Van, LG Montgomery, M Gurumurthy, M Introna, M Songane, M Zhang, MB Drennan, MG Drage, MJ Ma, MJ Newport, MM Hossain, Mohammad Reza Masjedi, N Najmi, N Reiling, N Reiling, NC Arbour, NT Thuong, O Takeuchi, P Fietta, P Hartmann, P Selvaraj, P Ye, P Ye, Payam Tabarsi, Peter J. Barnes, R Bryk, R Crevel Van, R Döffinger, R Medzhitov, R Olesen, RC Langen, S Ahmad, S Akira, S Akira, S Akira, S Akira, S Cui, S Davila, S Mariathasan, S Nakae, S Shi, SA Khader, SA Khader, SF Azfar, SL Doyle, SR Krutzik, SS Master, T Kawai, T Kawai, T Kawai, T Ulrichs, TJ Kang, TK Means, TK Means, TM Wozniak, V Quesniaux, V Vouret-Craviari, Y Bulut, Y Liu, Y Xue, Y Zhang   +136 more
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Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease [PDF]

, 2015
The pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of ...
A Baroja-Mazo, A Kuznik, A Lartigue, A Nair, A Yarilina, AM Piccinini, C Jiang, C Jin, C Ospelt, CL Baumann, CM Burns, CM Wang, CR Scanzello, CR Scanzello, D Jiang, D Loeuille, D Tang, DE Macfarlane, DH Kono, DH Sohn, DJ Connolly, E Latz, E Savarese, E Seki, F Brentano, F Hu, F Martinon, F Martinon, FG Goh, G Barreto, G Obermoser, Giselle Chamberlain, H Bernuth von, H Wardemann, HK Lee, HO Sweet, HS Youn, HY Yang, J Choi, JE Molineros, K Bobacz, K Midwood, K Neumann, K Oelke, K Schroder, K Yokota, L Bacconnier, L Sun, LA O'Neill, LE Munoz, Lisa M Mullen, LV Walle, M Carrion, M Feldmann, M Nakashima, MC Boissier, MF Roelofs, ML Santiago-Raber, ND Chamberlain, O Alvarez-Garcia, P Emery, PA Gibilisco, PS Chockalingam, PW Noble, R Baccala, R Liu-Bryan, R Liu-Bryan, R Thwaites, RC Coll, RM Pope, S Abdollahi-Roodsaz, S Abdollahi-Roodsaz, S Abdollahi-Roodsaz, S Alzabin, S Nasi, S Rakoff-Nahoum, SA Schattgen, Sandra Sacre, SL Su, SM Sacre, SM Sacre, SN Ultaigh, SY Chen, SY Lee, T Dorner, T Kawai, T Misawa, TB Geijtenbeek, TB Niewold, TH Mogensen, TH Tran, V Gagne, W Zhang, W Zhang, WJ McCormack, X Chevalier, Y Zhong   +96 more
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Primary immunodeficiencies of pattern recognition receptors [PDF]

Journal of Internal Medicine, 2012
AbstractPrimary immunodeficiencies (PIDs) are severe defects in the capacity of the host to mount a proper immune response, and are characterized by an increased susceptibility to infections. Although classical immunodeficiencies have been characterized based on broad defects in cell populations (e.g.
Netea, M.G., van de Veerdonk, F.L., Meer, J.W.M. van der   +2 more
openaire   +3 more sources

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) [PDF]

, 2011
The RIP kinases have emerged as essential mediators of cellular stress that integrate both extracellular stimuli emanating from various cell-surface receptors and signals coming from intracellular pattern recognition receptors.
Bertrand, Mathieu, Lippens, Saskia, Staes, An, Gilbert, Barbara, Roelandt, Ria, De Medts, Jelle, Gevaert, Kris, Declercq, Wim, Vandenabeele, Peter   +8 more
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Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
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Pattern-recognition receptors in airway inflammation [PDF]

, 2011
Airway inflammation is a defining feature of allergic rhinitis and asthma. Bacterial and viral infections are known to cause exacerbations of both diseases, but knowledge about the mechanisms involved is limited. The pattern-recognition receptors (PRRs)
Ekman, Anna-Karin
core   +1 more source

Pattern‐recognition receptors in human eosinophils [PDF]

Immunology, 2012
SummaryThe pattern‐recognition receptor (PRR) family includes Toll‐like receptors (TLRs), nucleotide‐binding oligomerization domain (NOD) ‐like receptors (NLRs), RIG‐I‐like receptors (RLRs), C‐type lectin receptors (CLRs) and the receptor for advanced glycation end products (RAGE).
Anne Månsson, Kvarnhammar, Lars Olaf, Cardell   +1 more
openaire   +2 more sources

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
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Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]

, 2017
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core   +1 more source