Results 21 to 30 of about 401,379 (287)

Anti-Viral Pattern Recognition Receptors as Therapeutic Targets

Cells, 2021
Pattern recognition receptors (PRRs) play a central role in the inflammation that ensues following microbial infection by their recognition of molecular patterns present in invading microorganisms but also following tissue damage by recognising molecules
Conor Hennessy, Declan P. McKernan
doaj   +1 more source

Pattern recognition receptors as a double-edged sword in cancer

Frontiers in Immunology, 2015
The problem of cancer remains one of the most immense challenges to current biomedical research. Affecting populations in all countries and all regions, this disease is responsible for millions of deaths annually (1). Evasion of the immune system is an ominous feature of cancers, which often leads to tumor outgrowth, epithelial–mesenchymal transition ...
Anton G. Kutikhin, Arseniy E Yuzhalin
doaj   +3 more sources

Pattern recognition receptors

Japanese Journal of Clinical Immunology, 2011
Immunity is based on self/nonself discrimination. In vertebrates, two major systems, innate and adaptive immune systems, constitute host defense against invading microbes. Adaptive immunity is characterized by specific immune responses through B- or T-cell antigen receptors that are generated by somatic recombination, whereas nonspecific responses to ...
Takaya, Hayashi, Tohru, Nakamura, Akinori, Takaoka   +2 more
openaire   +4 more sources

Effect of human breast milk on innate immune response: Up-regulation of bacterial pattern recognition receptors and innate cytokines in THP-1 monocytic cells

European Journal of Inflammation, 2021
Human breast milk (HBM) contains many bioactive components that protect infants from various microorganisms. Pattern recognition receptors on phagocytic cells recognize microbial pathogens and promote the innate immune system.
Won-Ho Hahn, Soon Young Shin, Jun Hwan Song, Nam Mi Kang   +3 more
doaj   +1 more source

Intracellular PRRs Activation in Targeting the Immune Response Against Fungal Infections

Frontiers in Cellular and Infection Microbiology, 2020
The immune response against fungal infections is complex and exhibits several factors involving innate elements that participate in the interaction with the fungus. The innate immune system developed pattern recognition receptors that recognize different
Grasielle Pereira Jannuzzi, José Roberto Fogaça de Almeida, Larissa Neves Monteiro Paulo, Sandro Rogério de Almeida, Karen Spadari Ferreira   +4 more
doaj   +1 more source

Nature's soothing solution: Harnessing the potential of food-derived polysaccharides to control inflammation

Current Research in Structural Biology, 2023
Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers.
Lucas de Freitas Pedrosa, Paul de Vos, João Paulo Fabi   +2 more
doaj   +1 more source

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]

, 2014
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, Nicky J., Evans, David J., Simmonds, Peter, Witteveldt, Jeroen   +3 more
core   +2 more sources

Pattern recognition receptors as key players in adrenal gland dysfunction during sepsis [PDF]

, 2012
Background: Undergoing systemic inflammation, the innate immune system releases excessive proinflammatory mediators, which finally can lead to organ failure. Pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and NOD-like receptors (
Bornstein, Stefan R., Hoesker, Vanessa, Kanczkowski, Waldemar, Tran, Thi Hoai Nguyen, Zacharowski, Kai   +4 more
core   +1 more source

High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]

, 2016
The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon, Barahona, Baraquet, Berendsen, Boller, Burdette, Cao, Chinchilla, Clarke, Dangl, Dasgupta, Dong, Engl, Felix, Forsyth, Gal, Gomez-Gomez, Goymer, Guttman, Hann, Heese, Hengge, Hickman, Hickman, Jackson, Kazmierczak, Kovach, Kulasakara, Kunze, Lacombe, Lee, Li, Loon, Loper, Loper, Lugtenberg, Macho, Malone, Marino, Matilla, Miya, Newell, Nuhse, Peart, Pel, Perez-Mendoza, Plotnikova, Robleto, Rossez, Roux, Schulze, Schwessinger, Segonzac, Spangler, Starkey, Sun, Torres, Van Wees, Wang, Willmann, Winsor, Xin, Yan, Zamioudis, Zeng, Zhang, Zipfel, Zipfel, Zipfel   +68 more
core   +1 more source

The phylogenetically-related pattern recognition receptors EFR and XA21 recruit similar immune signaling components in monocots and dicots [PDF]

, 2015
During plant immunity, surface-localized pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). The transfer of PRRs between plant species is a promising strategy for engineering broad-spectrum disease resistance ...
A Afroz, A Farid, A Heese, AP Macho, B Schulze, B Schwessinger, BBH Wulff, BMJ Mendes, C Dardick, C Dardick, C Zipfel, CJ Park, CJ Park, CJ Park, CJ Park, CR Buell, Cyril Zipfel, D Chinchilla, DP Lu, DP Lu, EF Fradin, FG da Silva, FG Malinovsky, H Haweker, J Li, J Santiago, J Zhang, JL Dangl, JM Gagne, JM Gagne, JR Wan, K Bouwmeester, K Yamaguchi, L Gomez-Gomez, L Li, LA Boyd, LL Gao, M Albert, M Roux, MD Lehti-Shiu, MD Lehti-Shiu, N Tintor, Nicholas Holton, O Bahar, P Tang, Pamela C. Ronald, RC Edgar, S Burdman, S Lacombe, S Robatzek, SG Hwang, SH Shiu, SH Shiu, SH Shiu, SK Song, SM Chaw, T Boller, T Halter, T Sakamoto, V Nekrasov, Vladimir Nekrasov, W Lin, Wenbo Ma, WQ Zeng, WY Song, X Chen, X Lu, XF Xin, Y Kadota, Y Kawano, Y Shen, Y Sun, YD Sun, YJ Zan, YN Jiang, YS Wang, ZX Liu   +76 more
core   +12 more sources