Results 91 to 100 of about 3,342,563 (345)

Exploring DNA quality of single cells for genome analysis with simultaneous whole-genome amplification

Scientific Reports, 2018
Single cell genome analysis methods are powerful tools to define features of single cells and to identify differences between them. Since the DNA amount of a single cell is very limited, cellular DNA usually needs to be amplified by whole-genome ...
Christiane Bäumer, Evelyn Fisch, Holger Wedler, Frank Reinecke, Christian Korfhage   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

Analytical Chemistry, 2011
Digital PCR enables the absolute quantitation of nucleic acids in a sample. The lack of scalable and practical technologies for digital PCR implementation has hampered the widespread adoption of this inherently powerful technique. Here we describe a high-
B. Hindson, K. Ness, D. Masquelier, P. Belgrader, Nick Heredia, A. Makarewicz, Isaac J. Bright, M. Lucero, A. Hiddessen, T. Legler, Tyler K. Kitano, Michael R. Hodel, J. Petersen, Paul W Wyatt, Erin R. Steenblock, Pallavi H. Shah, L. Bousse, C. Troup, Jeff Mellen, Dean K. Wittmann, Nicholas G. Erndt, T. Cauley, R. Koehler, A. So, S. Dube, K. Rose, Luz Montesclaros, Shenglong Wang, D. Stumbo, Shawn Hodges, S. Romine, F. Milanovich, H. White, John F. Regan, G. Karlin-Neumann, Christopher M. Hindson, Serge Saxonov, B. Colston   +37 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A cardiac and subcutaneous canine dirofilariosis outbreak in a kennel in central France

Parasite, 2019
Canine dirofilarioses are nematode infections caused by two species of the genus Dirofilaria: D. immitis and D. repens. We describe here an outbreak of D. immitis and D.
Laidoudi Younes, Ringot David, Watier-Grillot Stéphanie, Davoust Bernard, Mediannikov Oleg   +4 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Influence of Container Volume and Cuttings Size on the Growth Parameters of Seedlings with a Closed Root System of Two Poplar Genotypes in the Voronezh Region

International Journal of Plant Biology
This study examined the bioproductivity of two poplar genotypes propagated by single-tree stem cuttings. The experiment compared variants using cuttings of different lengths (10–22 cm) and containers with volumes from 1 to 3 L. It was found that the best
Peter Evlakov, Alexey Tseplyaev, Anna Popova, Vladimir Zapletin, Vladlena Ryzhkova, Lyudmila Repnikova, Konstantin Zhuzhukin   +6 more
doaj   +1 more source

Validation of a multiplex-tandem RT-PCR for the detection of bovine respiratory disease complex using Scottish bovine lung samples

, 2023
Marı́a M. Fergusson, Madeleine Maley, Timothy Geraghty, J. Palarea Albaladejo, Colin Mason, Mara Rocchi   +5 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Confirmation of multi-parallel quantitative real-time PCR as the gold standard for detecting soil-transmitted helminths in stool [PDF]

, 2021
Marina Papaiakovou, Nils Pilotte, Julia C. Dunn, David TJ Littlewood, Rubén O. Cimino, Alejandro Krolewiecki, Steven A. Williams, Rojelio Mejía   +7 more
openalex   +1 more source