Results 41 to 50 of about 750,934 (136)

Blockade ofthe negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis [PDF]

, 2013
INTRODUCTION: Fungal sepsis is an increasingly common problem in intensive care unit patients.Mortality from fungal sepsis remains high despite antimicrobial therapy that is highly active against most fungal pathogens, a finding consistent with defective
Burnham, Carey-Ann, Chang, Katherine C, Compton, Stephanie M, Green, Jonathan M, Hotchkiss, Richard S, Korman, Alan J, Mazuski, Richard J, McDonough, Jacquelyn S, Rasche, David P, Unsinger, Jacqueline   +9 more
core   +2 more sources

PD-1: Dual guard for immunopathology

Oncotarget, 2015
Despite remarkable medical development, chronic infectious diseases caused by the infections with persistent pathogens such as hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and mycobacterium tuberculosis (M.tb), have not been conquered yet.
Hye Ryun, Kim, Hyo Jin, Park, Sang-Jun, Ha   +2 more
openaire   +3 more sources

Alterations of immune response of non-small lung cancer with azacytidine [PDF]

, 2013
Innovative therapies are needed for advanced Non-Small Cell Lung Cancer (NSCLC). We have undertaken a genomics based, hypothesis driving, approach to query an emerging potential that epigenetic therapy may sensitize to immune checkpoint therapy targeting
Baylin, Stephen B, Brahmer, Julie R, Brock, Malcolm V, Carvajal, Richard D, De Meyer, Tim, Du, Zhengzong, Easton, Keith, Easwaran, Hariharan, Jones, Peter A, Juergens, Rosalyn A, Koch, Alexander, Laird, Peter W, Mohammad, Helai P, Pardoll, Drew, Parsana, Princy, Rodgers, Kristen, Rudin, Charles M, Taube, Janis M, Topalian, Suzanne L, Tsai, Salina, Tykodi, Scott S, Van Criekinge, Wim, Vendetti, Frank, Wang, Wei, Weisenberger, Daniel J, Wrangle, John, Yen, Ray-Whay, Zahnow, Cynthia A   +27 more
core   +1 more source

Interpretation of some Yb-based valence-fluctuating crystals as approximants to a dodecagonal quasicrystal

, 2018
The hexagonal ZrNiAl-type (space group: P-62m) and the tetragonal Mo2FeB2-type (space group: P4/mbm) structures, which are frequently formed in the same Yb-based alloys and exhibit physical properties related to valence-fluctuation, can be regarded as ...
de Boissieu, Marc, Deguchi, Kazuhiko, Ishimasa, Tsutomu, Mihalkovič, Marek, Sato, Noriaki K.   +4 more
core   +2 more sources

Singular Oscillatory Integrals on R^n

, 2009
Let Pd,n denote the space of all real polynomials of degree at most d on R^n. We prove a new estimate for the logarithmic measure of the sublevel set of a polynomial P in Pd,1.
A. Carbery, I. R. Parissis, I.R. Parissis, M. Papadimitrakis   +3 more
core   +1 more source

Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity

BMC Immunology
Abstract Vanishing bile duct syndrome (VBDS) is a serious drug induced liver injury characterized by chronic cholestasis and loss of intrahepatic bile ducts. VBDS has been reported also following checkpoint inhibitor treatment. We compared CD3 + , CD4 + , CD8 + , CD20 + , CD57 + , PD-1 + and PD-L1 + lymphocyte infiltrates in liver biopsies of
Saarela, Miro, Parviainen, Essi, Lleo, Ana, di Tommaso, Luca, Raunio, Hanna, Kankaanranta, Krista, Vuopala, Katri, Rönkä, Aino, Nurmenniemi, Sini, Kallio, Raija, Jukkola, Arja, Selander, Katri S.   +11 more
openaire   +4 more sources

Striking enhancement at the site of radiation for nivolumab-induced Stevens-Johnson syndrome [PDF]

, 2018
Stevens-Johnson syndrome is a rare adverse cutaneous drug reaction characterized by epidermal detachment of
Al-Omari, Ahmed, Rancour, Elizabeth A., Shah, Kishan M.   +2 more
core  

The Fermi Surface Effect on Magnetic Interlayer Coupling

, 2004
The oscillating magnetic interlayer coupling of Fe over spacer layers consisting of Cu$_{x}$Pd$_{1-x}$ alloys is investigated by first principles density functional theory.
Anders Bergman, B. L. Györffy, Erik Holmström, H. Nyquist, I. A. Abrikosov, I. A. Abrikosov, K. Ohshima, K. Wildberger, Lars Nordström, O. Andersen, S. B. Dugdale   +10 more
core   +1 more source

PD-1 Inhibitor Becomes “Breakthrough Therapy” [PDF]

Cancer Discovery, 2013
Abstract Merck's lambrolizumab (MK-3475) monoclonal antibody received “Breakthrough Therapy” designation from the U.S. Food and Drug Administration in April for treating patients with advanced melanoma. The designation is one of many signs of progress in attacking cancer with agents designed for immune checkpoint blockade.
openaire   +2 more sources

PD‐1 targeting in cancer immunotherapy [PDF]

Cancer, 2012
This Web‐only perspective commentary discusses a new class of monoclonal antibodies that have garnered tremendous enthusiasm within the field of cancer immunotherapy, which has previously been hampered by complex, cumbersome agents and cells; individualized and laborious preparations; and questionable clinical efficacy.
openaire   +2 more sources