Results 61 to 70 of about 2,405 (181)

Epidemiology of porcine deltacoronavirus among Chinese pig populations in China: systematic review and meta-analysis

Frontiers in Veterinary Science, 2023
Porcine deltacoronavirus (PDCoV) is a newly emerging and important porcine enteropathogenic coronavirus that seriously threatens the swine industry in China and worldwide.
Junying Sun, Junying Sun, Junying Sun, Qin Zhang, Chunhong Zhang, Chunhong Zhang, Chunhong Zhang, Zhicheng Liu, Zhicheng Liu, Zhicheng Liu, Jianfeng Zhang, Jianfeng Zhang, Jianfeng Zhang   +12 more
doaj   +1 more source

Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection

Emerging Microbes and Infections, 2018
Porcine deltacoronavirus (PDCoV), a member of genus Deltacoronavirus, is an emerging swine enteropathogenic coronavirus (CoV). Although outstanding efforts have led to the identification of Alphacoronavirus and Betacoronavirus receptors, the receptor for
Xinyu Zhu, Shudan Liu, Xunlei Wang, Zhaochen Luo, Yuejun Shi, Dang Wang, Guiqing Peng, Huanchun Chen, Liurong Fang, Shaobo Xiao   +9 more
doaj   +1 more source

Integrin αVβ3 mediates porcine deltacoronavirus infection and inflammatory response through activation of the FAK-PI3K-AKT-nf-κB signalling pathway

Virulence
Porcine deltacoronavirus (PDCoV) is an emerging porcine enteropathogenic coronavirus that causes acute watery diarrhoea in piglets, resulting in significant economic losses to the global swine industry.
Xiaohui Jin, Xingyi Wu, Zehui Li, Yixin Hu, Lu Xia, Shaopo Zu, Gaiping Zhang, Hui Hu   +7 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

PDCoV nsp5 cleaves POLDIP3 through its protease activity.

, 2023
(A) PDCoV nsp5 cleaves POLDIP3. IPEC-J2 cells were co-transfected with plasmids of POLDIP3-HA and PDCoV nsp5-Flag or empty vector, and then cell samples were collected at 30 h post-transfection for Western blotting analysis.
Jianfei Chen (3186999), Jin Tian (158712), Haoxin Yan (17108715), Mingwei Li (1914862), Longjun Guo (315268), Yudi Pan (7309513), Hongyan Shi (1988656), Da Shi (1455439), Li Feng (77923), Yang Wu (66682)   +9 more
core   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Development and application of an ELISA for the detection of porcine deltacoronavirus IgG antibodies. [PDF]

PLoS ONE, 2015
Porcine deltacoronavirus (PDCoV), also known as porcine coronavirus HKU15, was first detected in North America in early 2014 and associated with enteric disease in pigs, resulting in an urgent need to further investigate the ecology of this virus.
Anil Thachil, Priscilla F Gerber, Chao-Ting Xiao, Yao-Wei Huang, Tanja Opriessnig   +4 more
doaj   +1 more source

A Rapid, Field‐Deployable Diagnostic Platform for Getah Virus Based on RT‐RAA and CRISPR EsCas13d

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
This study developed a rapid, one‐step, visual detection platform termed ROSVD by integrating RT‐RAA with CRISPR–EsCas13d, enabling simplified sample preparation, high‐sensitivity, on‐site detection of GETV within 30 min without the need for sophisticated equipment.
Liu Baoling, Shao Lina, Xu Tong, Jia Qinrui, Zhu Ling, Xu Zhiwen   +5 more
wiley   +1 more source

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure‐Enabled Lateral Flow Assay

Advanced Healthcare Materials, Volume 15, Issue 26, 10 July 2026.
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao, Akhila Naru, Dhanush Gandavadi, Mengxi Zheng, Saraswathi Lanka, Hyeongjun Cho, Chau Nguyen Minh Hoang, Jianqiang Zhang, Ying Fang, Xing Wang   +9 more
wiley   +1 more source