Results 71 to 80 of about 2,664 (192)

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

Advanced Science, Volume 12, Issue 33, September 4, 2025.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu, Suhui He, Wen Shi, Jinxia Xu, Shiyang Liu, Zexu Yu, Danyue Li, Qiao Jin, Yumeng Wang, Zian Zhang, Qian Lv, Yuanxiang Ge, Yunjie Li, Xinyue Li, Nan Chen, Xinyu Fu, Yang Yang, Fushan Shi   +17 more
wiley   +1 more source

Effects of SADS‐CoV accessory proteins NS3a, NS7a, and NS7b on viral pathogenicity: A multi‐omics investigation

iMetaOmics, Volume 2, Issue 3, September 2025.
This study has elucidated the role of three swine acute diarrhea syndrome coronavirus (SADS‐CoV) accessory proteins in influencing viral pathogenicity and preliminarily explored the host molecular targets and pathways affected by the NS3a, NS7a, and NS7b proteins of SADS‐CoV.
Xiaoling Yan, Xiaoli Zhang, Ling Zhou, Xiaoya Zhao, Qianniu Li, Tian Lan, Jun Fu, Jingyun Ma   +7 more
wiley   +1 more source

A novel genotyping system based on site polymorphism on spike gene reveals the evolutionary pathway of porcine epidemic diarrhea virus

iMetaOmics, Volume 2, Issue 2, June 2025.
This study focuses on porcine epidemic diarrhea virus (PEDV), a highly virulent and rapidly evolving coronavirus threatening global swine production. We established a novel genotype system of PEDV targeting site‐specific polymorphisms in the spike (S) protein.
Mingkai Lei, Huimin Li, Xiaoyu Chen, Xiaozhen Li, Xuexiang Yu, Shengnan Ruan, Hao Wu, Ahmed H. Ghonaim, Ziyang Yan, Wentao Li, Qigai He   +10 more
wiley   +1 more source

Evaluation of serological cross-reactivity and cross-neutralization between the United States porcine epidemic diarrhea virus prototype and S-INDEL-variant strains [PDF]

, 2016
BACKGROUND: At least two genetically different porcine epidemic diarrhea virus (PEDV) strains have been identified in the United States (U.S. PEDV prototype and S-INDEL-variant strains).
CM Lin, D Goede, D Marthaler, D Song, D Sun, Darin M. Madson, DM Madson, Drew R. Magstadt, F Okda, Ganwu Li, GW Stevenson, J Lowe, J Pasick, J Zhang, Jianqiang Zhang, John M. Hardham, Joseph T. Thomas, JT Thomas, L Wang, LG Gimenez-Lirola, Luis G. Giménez-Lirola, PF Gerber, Phillip C. Gauger, Priscilla F. Gerber, Q Chen, Qi Chen, Qinshan Gao, T Oka, Tanja Opriessnig, Ying Zheng, YW Huang   +30 more
core   +3 more sources

Establishment and application of a dual chip digital PCR assay for detection of PDCoV and PEDV. [PDF]

Front Vet Sci
IntroductionCoinfection with porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV) is a major cause of acute diarrhea in piglets, which poses a significant challenge to the swine industry. The early detection and control of these two viruses require highly sensitive diagnostic tools.
Zhang Y, Dong F, Zhang Y, Feng Y, Hu J, Li Y, Xia L, Zu S, Lu H, Wei Z.   +9 more
europepmc   +3 more sources

Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection

Emerging Microbes and Infections
Porcine deltacoronavirus (PDCoV) is an emerging pathogen that can cause severe diarrhoea and high mortality in suckling piglets. Moreover, evidence of PDCoV infection in humans has raised concerns regarding potential public health risks.
Ningning Ma, Mengjia Zhang, Jiaru Zhou, Changsheng Jiang, Ahmed H. Ghonaim, Yumei Sun, Pei Zhou, Guanghao Guo, Anouk Evers, Hongmei Zhu, Qigai He, Robert Jan Lebbink, Berend Jan Bosch, Wentao Li   +13 more
doaj   +1 more source

Application of microfluidic technologies in veterinary science with a view toward development of animal‐on‐a‐chip models

VIEW, Volume 6, Issue 1, February 2025.
Other than human‐based application, it is important for microfluidics technology to be integrated in the field of veterinary science. With current but limited existing studies and experience from plenty of human‐oriented microfluidics applications, microfluidics technologies will bring tremendous benefit to the welfare and healthcare of various animal ...
Qiankun Yin, Zhenxu Yang, Shin Wei Chong, Jiarong Li, Xiaochen Liu, Daniele Vigolo, Jiao Jiao Li, Paul A. Sheehy, Ken‐Tye Yong   +8 more
wiley   +1 more source

Detection of swine emerging viruses by Real-time PCR and histopathological examination of tissue lesions in domestic pigs (Sus scrofa domesticus) in Sardinia [PDF]

, 2023
Population growth leads to global meat consumption and production increase. In Italy, pork production plays an important economic role. In Sardinia, pork-producing farms are familiar, and intensive farms are uncommon.
HAWKO, SALWA
core  

Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design

Emerging Microbes and Infections, 2020
Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus that causes severe diarrhea, resulting in high mortality in neonatal piglets. Despite widespread outbreaks in many countries, no effective PDCoV vaccines are currently available.
Mengjia Zhang, Wan Li, Peng Zhou, Dejian Liu, Rui Luo, Anan Jongkaewwattana, Qigai He   +6 more
doaj   +1 more source

Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein [PDF]

Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that has recently been detected in humans. Despite this zoonotic concern, the antigenic structure of PDCoV remains unknown.
Bosch, Berend Jan, Debski-Antoniak, Oliver, Drabek, Dubravka, Drulyte, Ieva, Du, Wenjuan, Grosveld, Frank, Hurdiss, Daniel L., van der Lee, Joline, van Dortmondt, Melissa, van Haperen, Rien, van Kuppeveld, Frank J.M.   +10 more
core   +2 more sources