Results 71 to 80 of about 2,405 (181)

Intranasal administration with recombinant vaccine PRVXJ-delgE/gI/TK-S induces strong intestinal mucosal immune responses against PDCoV

, 2023
Porcine deltacoronavirus (PDCoV) is a novel coronavirus that causes enteric diseases in pigs leading to substantial financial losses within the industry.
Lishuang Deng, Zhiwen Xu, Bingzhou Huang, Ling Zhu, Zhijie Jian, Yanru Ai, Tong Xu, Yao Huang, Siyuan Lai   +8 more
core   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection

Emerging Microbes and Infections
Porcine deltacoronavirus (PDCoV) is an emerging pathogen that can cause severe diarrhoea and high mortality in suckling piglets. Moreover, evidence of PDCoV infection in humans has raised concerns regarding potential public health risks.
Ningning Ma, Mengjia Zhang, Jiaru Zhou, Changsheng Jiang, Ahmed H. Ghonaim, Yumei Sun, Pei Zhou, Guanghao Guo, Anouk Evers, Hongmei Zhu, Qigai He, Robert Jan Lebbink, Berend Jan Bosch, Wentao Li   +13 more
doaj   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding, Wenhao Li, Ling Mei, Suling Luo, Jing Tao, Chongxiu Shi, Hongping Yang, Wei Feng, Yungchang Chen, Yu Chen, Jong Seung Kim, Xue Shen   +11 more
wiley   +1 more source

PDCoV nsp5 cleaves POLDIP3 at residue glutamine 176 (Q176).

, 2023
(A) Logo analysis of the cleavage site predicted by WebLogo (http://weblogo.threeplusone.com/), based on the polyprotein and other substrates cleavage of PDCoV nsp5. (B) Schematic representation of POLDIP3 and its mutant sites.
Jianfei Chen (3186999), Jin Tian (158712), Haoxin Yan (17108715), Mingwei Li (1914862), Longjun Guo (315268), Yudi Pan (7309513), Hongyan Shi (1988656), Da Shi (1455439), Li Feng (77923), Yang Wu (66682)   +9 more
core   +1 more source

Nanoparticle vaccines based on the receptor binding domain of porcine deltacoronavirus elicit robust protective immune responses in mice

Frontiers in Immunology
BackgroundPorcine deltacoronavirus (PDCoV), a novel swine enteropathogenic coronavirus, challenges the global swine industry. Currently, there are no approaches preventing swine from PDCoV infection.MethodsA new PDCoV strain named JS2211 was isolated ...
Yuanhong Wang, Junhan Song, Xiaoying Deng, Junna Wang, Miao Zhang, Yun Liu, Pan Tang, Huili Liu, Yanjun Zhou, Guangzhi Tong, Guoxin Li, Guoxin Li, Lingxue Yu, Lingxue Yu   +13 more
doaj   +1 more source

Genetic Diversity, Recombination, and Pathogenicity of Porcine Epidemic Diarrhea Virus Strains Circulating in China During 2023–2024

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine epidemic diarrhea virus (PEDV) is an enteric alphacoronavirus that causes severe diarrhea and high mortality in neonatal piglets, posing a persistent threat to the global swine industry. Despite extensive vaccination, PEDV continues to circulate in China, underscoring the need for updated molecular epidemiological surveillance.
Yunlei Cao, Ahui Cui, Xin Chen, Yang Cheng, Rongfeng Tang, Hui Zeng, Yuchen Li, Qian Yang, Linzhu Ren   +8 more
wiley   +1 more source

Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination

Frontiers in Immunology, 2019
Porcine deltacoronavirus (PDCoV) is a newly detected porcine coronavirus causing serious vomiting and diarrhea in piglets, especially newborn piglets. There has been an outbreak of PDCoV in worldwide since 2014, causing significant economic losses in the
Ji Likai, Li Shasha, Zhu Wenxian, Ma Jingjiao, Sun Jianhe, Wang Hengan, Yan Yaxian   +6 more
doaj   +1 more source

Discovery of Cetaben as a Novel Antiviral Agent Against Porcine Epidemic Diarrhea Virus From a Cholesterol‐Lowering Compound Library

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The devastating impact of porcine epidemic diarrhea virus (PEDV) on the global swine industry underscores an urgent need for effective antiviral therapies. Drug repurposing presents a promising strategy to accelerate the development of such treatments.
Yaqin Li, Panpan Qin, Kaiqi Zhang, Ningning Ma, Tianliang Wang, Zilu Chen, Yixin Yuan, Dongliang Li, Linyang Yu, Wentao Li, Wenjuan Du, Yongtao Li, Jianchao Wei   +12 more
wiley   +1 more source