Results 41 to 50 of about 3,909 (203)
Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis [PDF]
, 2017 Removal of renal mass stimulates anatomical and functional adaptations in the surviving nephrons, including elevations in single-nephron glomerular filtration rate (SNGFR) and tubular hypertrophy. A goal of this study is to assess the extent to which the
Edwards, Aurelie +2 more
core +1 more source
The Renal Physiology of Pendrin-Positive Intercalated Cells [PDF]
Physiological Reviews, 2020 Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl−absorption and HCO3−secretion, largely through the anion exchanger pendrin.
Susan M. Wall +2 more
openaire +2 more sources
Cellular Physiology and Biochemistry, 2013 Background: We recently reported that aquaporin 5 (AQP5), a water channel never identified in the kidney before, co-localizes with pendrin at the apical membrane of type-B intercalated cells in the kidney cortex.
Giuseppe Procino +11 more
doaj +1 more source
Two Compound Heterozygous Were Identified in Gene in Two Chinese Families With Enlarged Vestibular Aqueduct [PDF]
Clinical and Experimental Otorhinolaryngology, 2019 Objectives To investigate the genetic causes of hearing loss with enlarged vestibular aqueduct (EVA) in two children from unrelated two Chinese families. Methods Sanger sequencing of all coding exons in SLC26A4 (encoding Pendrin protein) was performed on
Yongbo Yu +11 more
doaj +1 more source
Modus operandi of ClC-K2 Cl− Channel in the Collecting Duct Intercalated Cells
Biomolecules, 2023 The renal collecting duct is known to play a critical role in many physiological processes, including systemic water–electrolyte homeostasis, acid–base balance, and the salt sensitivity of blood pressure.
Anna Stavniichuk +5 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2013 Background and Aims: The thiazide-sensitive Na+-Cl- cotransporter NCC and the Cl-/HCO3-exchanger pendrin are expressed on apical membranes of distal cortical nephron segments and mediate salt absorption, with pendrin working in tandem with the epithelial
Jie Xu +3 more
doaj +1 more source
Pendrin—A New Target for Diuretic Therapy? [PDF]
Journal of the American Society of Nephrology, 2016 Diuretics are among the most frequently used drugs to treat hypertension, congestive heart failure, and edema and play a role in the prevention of some forms of recurrent nephrolithiasis.[1][1]–[3][2] Most commonly used diuretics act by directly inhibiting tubular transport processes, such as ...
openaire +3 more sources
FASEB BioAdvances, 2020 Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete anions from epithelia.
Jeffrey Bajko +4 more
doaj +1 more source
Mimicry and well known genetic friends: molecular diagnosis in an Iranian cohort of suspected Bartter syndrome and proposition of an algorithm for clinical differential diagnosis. [PDF]
, 2019 BACKGROUND: Bartter Syndrome is a rare, genetically heterogeneous, mainly autosomal recessively inherited condition characterized by hypochloremic hypokalemic metabolic alkalosis.
A Bettinelli +49 more
core +3 more sources
Regulation of pendrin by pH: dependence on glycosylation [PDF]
Biochemical Journal, 2011 Mutations in the anion exchanger pendrin are responsible for Pendred syndrome, an autosomal recessive disease characterized by deafness and goitre. Pendrin is highly expressed in kidney collecting ducts, where it acts as a chloride/bicarbonate exchanger and thereby contributes to the regulation of acid–base homoeostasis and blood pressure.
Azroyan, Anie +5 more
openaire +3 more sources