Results 151 to 160 of about 51,168 (257)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Somatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs. [PDF]

Sci Adv
McGivney GR, Brockman QR, Borcherding N, Scherer A, Rauckhorst AJ, Gutierrez WR, Solst SR, Heer CD, Warrier A, Floyd W, Kirsch DG, Knepper-Adrian VL, Laverty EA, Roughton GA, Spitz DR, Taylor EB, Dodd RD.   +16 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

YAP-activated NAT10 promotes hepatoblastoma progression by activating the pentose phosphate pathway. [PDF]

Int J Biol Sci
Wang L, Yang S, Li J, Fang Y, Guo M, Du X, Song L, Chen S, Zhang X, Qi Z, Zhang K, Lv B, Xia J.   +12 more
europepmc   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

The Pentose Phosphate Pathway: From Mechanisms to Implications for Gastrointestinal Cancers. [PDF]

Int J Mol Sci
Qiao J, Yu Z, Zhou H, Wang W, Wu H, Ye J.   +5 more
europepmc   +1 more source

A Comprehensive Review on Xylitol Production: Experimental and Theoretical Insights, Research Gaps, and Future Perspectives

Advanced Energy and Sustainability Research, Volume 7, Issue 6, June 2026.
This review integrates chemical and biological xylitol production from upstream to downstream, uniquely combining experimental and theoretical insights to reveal mechanisms, bottlenecks, and future directions for sustainable lignocellulosic xylitol production.
Tanongsak Sukkasem, Pratikkumar Lakhani, Atthapon Srifa   +2 more
wiley   +1 more source

Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Sex differences are increasingly recognized as central to the biology of Alzheimer's disease (AD), yet the mechanisms through which they shape brain metabolism and disease vulnerability remain incompletely understood. Brain glucose hypometabolism is a core hallmark of AD and emerges decades before clinical decline, but accumulating evidence ...
Marjan Ramezan, Aphrodite Demetriou, Sara Nicole Burke, Ivan Nalvarte, Andrew C. Shin   +4 more
wiley   +1 more source

TKT regulates the pentose phosphate pathway via RBKS to promote epithelial-mesenchymal transition during AML progression. [PDF]

J Bioenerg Biomembr
Li F, Liu J, Geng Y, Liu L, Li J, Pu L, Hu Z, Yang Y.   +7 more
europepmc   +1 more source