Results 171 to 180 of about 51,168 (257)

High‐Altitude Hypoxia Activates JNK‐p53 Signaling: Linking Hippocampal Energy Crisis to Cognitive Impairment

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Chronic high‐altitude hypoxia impairs memory in 2819 residents and causes hippocampal atrophy in rats. JNK‐p53‐Bim signaling drives mitophagy‐to‐apoptosis transition and 73% ATP depletion, while concurrent HIF‐2α/PHD2 activation indicates parallel adaptive responses.
Guisheng Hao, Zhengzhong Bai, Wenjuan Wang, Jian Wu, Fan Zheng, Guoen Jin, Ri‐Li Ge   +6 more
wiley   +1 more source

Pentose-phosphate pathway disruption in the pathogenesis of Parkinson’s disease

Translational Neuroscience, 2014
Dunn Laura, Fairfield Vanessa, Daham Shanay, Bolaños Juan, Heales Simon   +4 more
doaj   +1 more source

STING exerts antiviral innate immune response by activating pentose phosphate pathway. [PDF]

Cell Commun Signal
Wu DH, Zhao ZL, Yin WT, Liu H, Xiang XY, Zhu LJ, Li JQ, Yan ZH, Li YJ, Jian YP, Xu ZX.   +10 more
europepmc   +1 more source

Enzymatic Synthesis of NAD+

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite involved in numerous biological processes, functioning both as a redox cofactor in cellular energy metabolism and as a co‐substrate for NAD+‐utilizing enzymes, including sirtuins and poly(ADP‐ribose) polymerases.
Emily Boyle, Olivia Zhang, Yana Cen
wiley   +1 more source

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes. [PDF]

Nat Metab
Loopmans S, Rohlenova K, van Brussel T, Stockmans I, Moermans K, Peredo N, Carmeliet P, Lambrechts D, Stegen S, Carmeliet G.   +9 more
europepmc   +1 more source

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This study explored the role of the class IIa histone deacetylase HDAC7 in hepatic inflammation and metabolic disease. Genetic approaches in mice revealed that myeloid HDAC7 drives hepatic inflammation and gene signatures associated with advanced chronic liver disease.
Yizhuo Wang, Divya Ramnath, Kaustav Das Gupta, P Prakrithi, Kavita Bisht, Gregory C Miller, Zherui Xiong, Yujun Wan, Ellen N Tejo, James EB Curson, Rishika Abrol, Sahar Keshvari, Kimberley S Gunther, Jordan D Atkinson, Zhixuan Loh, Jessica A Engel, Christian R Engwerda, Sabrina Sofia Burgener, Kate Schroder, David P Fairlie, Andrew D Clouston, Elizabeth E Powell, Katharine M Irvine, Mitchell A Sullivan, Jean‐Pierre Lévesque, Quan Nguyen, Matthew J Sweet, Denuja Karunakaran   +27 more
wiley   +1 more source

SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway. [PDF]

Commun Biol
Gong Y, Gao D, Shi Y, Fan G, Yu X, Yang E, Cheng H, Tian J, Ding H, Liu S, Fu S, Tao Y, Shui Y, Cheng L, Li L, Wang Z.   +15 more
europepmc   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, Volume 11, Issue 3, Page 1036-1045, June 2026.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Progesterone increases metabolism via the pentose phosphate pathway in bovine uterine epithelial cells. [PDF]

Mol Biol Rep
Berg MD, Braz CU, Dean M.
europepmc   +1 more source

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, Volume 6, Issue 3, June 2026.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source