Results 11 to 20 of about 319,110 (303)
Structural Basis for the Peptidoglycan-Editing Activity of YfiH
mBio, 2022 Bacterial cells are encased in peptidoglycan (PG), a polymer of disaccharide N-acetylglucosamine (GlcNAc) and N-acetyl-muramic acid (MurNAc) cross-linked by peptide stems.
Meng-Sheng Lee +6 more
doaj +1 more source
mBio, 2020 Nonribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs) play a pivotal role in the production of bioactive natural products, such as antibiotics and cytotoxins. Despite biomedical and pharmaceutical importance, the molecular mechanisms
A. Gacek-Matthews +5 more
doaj +1 more source
Journal of Nanobiotechnology, 2022 Abundant glutathione (GSH) is a biological characteristic of lots of tumor cells. A growing number of studies are utilizing GSH depletion as an effective adjuvant therapy for tumor.
Yang Gao +8 more
doaj +1 more source
A Nonribosomal System of Peptide Biosynthesis [PDF]
European Journal of Biochemistry, 1996 This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures.
H, Kleinkauf, H, Von Döhren
openaire +2 more sources
Endogenous cross-talk of fungal metabolites.
Frontiers in Microbiology, 2015 Non-ribosomal peptide synthesis in fungi requires a ready supply of proteogenic and non-proteogenic amino acids which are subsequently incorporated into the nascent non-ribosomal peptide via a thiotemplate mechanism catalysed by non-ribosomal peptide ...
Kevin J Sheridan +2 more
doaj +1 more source
Frontiers in Marine Science, 2021 C-type allatostatins (C-type ASTs) are a family of structurally related neuropeptides found in a wide range of insects and crustaceans. To date, the C-type allatostatin receptor in crustaceans has not been deorphaned, and little is known about its ...
An Liu +3 more
doaj +1 more source
Toxins, 2013 Polyketide synthase (PKSs) and nonribosomal peptide synthetase (NRPSs) are large multimodular enzymes involved in biosynthesis of polyketide and peptide toxins produced by fungi.
Massimo Ferrara +2 more
doaj +1 more source
Bioprocess Development for Lantibiotic Ruminococcin-A Production in Escherichia coli and Kinetic Insights Into LanM Enzymes Catalysis [PDF]
, 2019 Ruminococcin-A (RumA) is a peptide antibiotic with post-translational modifications including thioether cross-links formed from non-canonical amino acids, called lanthionines, synthesized by a dedicated lanthionine-generating enzyme RumM.
Adrian, Lorenz +5 more
core +1 more source
The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]
, 2012 There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Amy J. Gerc +5 more
core +3 more sources
Structure analysis of biologically important prokaryotic glycopolymers [PDF]
, 2013 Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria +1 more
core +1 more source