Results 11 to 20 of about 359,289 (223)
Medical Countermeasures against Ricin Intoxication
Toxins, 2023 Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil +1 more
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Control of translation elongation in health and disease
Disease Models & Mechanisms, 2020 Regulation of protein synthesis makes a major contribution to post-transcriptional control pathways. During disease, or under stress, cells initiate processes to reprogramme protein synthesis and thus orchestrate the appropriate cellular response. Recent
John R. P. Knight +12 more
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Further Evidence that Elongation Factor 1 Remains Bound to Ribosomes during Peptide Chain Elongation [PDF]
European Journal of Biochemistry, 1977 This paper describes three types of experiments which indicate that the binding sites for elongation factor 1 (EF‐1) and elongation factor 2 (EF‐2) on ascites cell ribosomes are not identical and perhaps not even overlapping. The experimental evidence presented includes direct competitive binding of labeled elongation factors to ribosomes as well as ...
H, Grasmuk, R D, Nolan, J, Drews
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Frontiers in Microbiology, 2022 Bacterial cell wall contains peptidoglycan (PG) to protect the cells from turgor and environmental stress. PG consists of polymeric glycans cross-linked with each other by short peptide chains and forms an elastic mesh-like sacculus around the ...
Pavan Kumar Chodisetti +3 more
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Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]
, 2020 Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P. +18 more
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Specific peptide-activated proteolytic cleavage of Escherichia coli elongation factor Tu [PDF]
Proceedings of the National Academy of Sciences, 1998 Phage exclusion is a form of programmed cell death in prokaryotes in which death is triggered by infection with phage, a seemingly altruistic response that limits multiplication of the phage and its spread through the population. One of the best-characterized examples of phage exclusion is the exclusion of T-even phages such as T4 by the ...
T, Georgiou +7 more
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Kinetics of initiating polypeptide elongation in an IRES-dependent system
eLife, 2016 The intergenic IRES of Cricket Paralysis Virus (CrPV-IRES) forms a tight complex with 80S ribosomes capable of initiating the cell-free synthesis of complete proteins in the absence of initiation factors. Such synthesis raises the question of what effect
Haibo Zhang +3 more
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Atrioventricular Conduction Abnormalities in Multisystem Inflammatory Syndrome in Children
Case Reports in Pediatrics, 2021 Cardiac manifestations in multisystem inflammatory syndrome in children (MIS-C) can include coronary artery aneurysms, left ventricular systolic dysfunction, and electrocardiographic disturbances.
Carlos A. Carmona +3 more
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Tomato EF-Tsmt, a functional mitochondrial translation elongation factor from higher plants [PDF]
, 2003 Ethylene-induced ripening in tomato (Lycopersicon esculentum) resulted in the accumulation of a transcript designated LeEF-Tsmt that encodes a protein with significant homology to bacterial Ts translational elongation factor (EF-Ts).
Benichou, Mohamed +10 more
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Toxins, 2016 Ricin is a type 2 ribosome-inactivating protein (RIP), containing a catalytic A chain and a lectin-like B chain. It inhibits protein synthesis by depurinating the N-glycosidic bond at α-sarcin/ricin loop (SRL) of the 28S rRNA, which thereby prevents the ...
Wei-Wei Shi +5 more
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