Results 91 to 100 of about 473,795 (256)
Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]
, 2013 Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason +5 more
core +1 more source
Improved de novo peptide sequencing using LC retention time information
Algorithms for Molecular Biology, 2018 Background Liquid chromatography combined with tandem mass spectrometry is an important tool in proteomics for peptide identification. Liquid chromatography temporally separates the peptides in a sample.
Yves Frank +3 more
doaj +1 more source
Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication [PDF]
, 2011 Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA) replication in vertebrates. Association between Treslin and TopBP1 requires cyclin-dependent kinase (Cdk) activity in Xenopus laevis egg extracts.
Dunphy, William G. +3 more
core +2 more sources
Two-dimensional partial covariance mass spectrometry for the top-down analysis of intact proteins [PDF]
arXiv, 2020 Two-dimensional partial covariance mass spectrometry (2D-PC-MS) exploits the inherent fluctuations of fragment ion abundances across a series of tandem mass spectra, to identify correlated pairs of fragment ions produced along the same fragmentation pathway of the same parent (e.g. peptide) ion. Here, we apply 2D-PC-MS to the analysis of intact protein
arxiv
A general reaction network unifies the aggregation behaviour of the A$β$42 peptide and its variants [PDF]
, 2016 The amyloid $\beta$ peptide (A$\beta$42), whose aggregation is associated with Alzheimer's disease, is an amphiphatic peptide with a high propensity to self-assemble. A$\beta$42 has a net negative charge at physiological pH and modulations of intermolecular electrostatic interactions can significantly alter its aggregation behaviour.
arxiv +1 more source
, 2011 International audienceElectron capture dissociation (ECD) of a series of five residue peptides led to the observation that these small peptides did not lead to the formation of the usual c/z ECD fragments, but to a, b, y and w fragments.
Chamot-Rooke, Julia +3 more
core +1 more source
Urinary CE-MS peptide marker pattern for detection of solid tumors [PDF]
, 2018 Urinary profiling datasets, previously acquired by capillary electrophoresis coupled to mass-spectrometry were investigated to identify a general urinary marker pattern for detection of solid tumors by targeting common systemic events associated with ...
Belczacka, Iwona +8 more
core +2 more sources
Microorganisms, 2020 The growing problem of antimicrobial resistance highlights the need for alternative strategies to combat infections. From this perspective, there is a considerable interest in natural molecules obtained from different sources, which are shown to be ...
Tecla Ciociola +6 more
doaj +1 more source
Generalized-Ensemble Simulations of the Human Parathyroid Hormone Fragment PTH(1-34) [PDF]
, 2003 A generalized-ensemble technique, multicanonical sampling, is used to study the folding of a 34-residue human parathyroid hormone fragment. An all-atom model of the peptide is employed and the protein-solvent interactions are approximated by an implicit solvent. Our results demonstrate that generalized-ensemble simulations are well suited to sample low-
arxiv +1 more source
Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups [PDF]
, 2017 Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions.
Gaya, Daniel +9 more
core +2 more sources