Towards protein-protein docking with significant structural changes using CABS-dock [PDF]
arXiv, 2016 The protein-protein interactions (PPIs) are crucial for understanding the majority of cellular processes. PPIs play important role in gene transcription regulation, cellular signaling, molecular basis of immune response and more. Moreover, a disruption of hese mechanisms is frequently postulated as a possible cause of diseases such as Alzheimer's or ...
arxiv
Chymotryptic and tryptic peptides of fragment α1-CB3 from bovine corneal collagen. Pinpointing the sites of hexose attachment [PDF]
, 1978 Naim Panjwani, John J. Harding
openalex +1 more source
Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission. [PDF]
Front Immunol, 2021 Mariotton J +11 more
europepmc +1 more source
NovoBench: Benchmarking Deep Learning-based De Novo Peptide Sequencing Methods in Proteomics [PDF]
arXivTandem mass spectrometry has played a pivotal role in advancing proteomics, enabling the high-throughput analysis of protein composition in biological tissues. Many deep learning methods have been developed for \emph{de novo} peptide sequencing task, i.e., predicting the peptide sequence for the observed mass spectrum.
arxiv
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Symbiotic NCR Peptide Fragments Affect the Viability, Morphology and Biofilm Formation of Candida Species. [PDF]
Int J Mol Sci, 2021 Szerencsés B +10 more
europepmc +1 more source
Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT [PDF]
, 2020 Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates.
Agrawal, Namita +10 more
core
Advanced Healthcare Materials, EarlyView.Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han +7 more
wiley +1 more source
Development of natural and unnatural amino acid delivery systems against hookworm infection
Precision Nanomedicine, 2020 Peptide-based vaccines consist of short antigen fragments derived from a specific pathogen. Alone, these peptide fragments are poorly or non-immunogenic; however, when incorporated into a proper delivery system, they can trigger strong immune responses.
Stacey Bartlett +5 more
doaj +1 more source