Results 271 to 280 of about 473,894 (355)
Advanced Science, EarlyView.This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini +8 more
wiley +1 more source
Highly amyloidogenic two-chain peptide fragments are released upon partial digestion of insulin with pepsin. [PDF]
J Biol Chem, 2015 Piejko M +6 more
europepmc +1 more source
A N‐terminal PTHrP peptide fragment void of a PTH/PTHrP‐receptor binding domain activates cardiac ETA receptors [PDF]
, 2001 Klaus‐Dieter Schlüter +2 more
openalex +1 more source
hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation
Advanced Science, EarlyView.This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang +13 more
wiley +1 more source
Advanced Science, EarlyView.The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du +9 more
wiley +1 more source
Pronase E-Based Generation of Fluorescent Peptide Fragments: Tracking Intracellular Peptide Fate in Single Cells. [PDF]
Anal Chem, 2015 Mainz ER, Dobes NC, Allbritton NL.
europepmc +1 more source
Advanced Science, EarlyView.Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang +11 more
wiley +1 more source
Advanced Science, EarlyView.We present a universal way to wrap liposomes around coacervate droplets. Membrane‐enclosed coacervates form when heat‐destabilized liposomes are mixed with coacervates. Membranized coacervates (MCs) can survive pH and ionic strength fluctuations, osmotic stress, and low temperatures.
Sadaf Javed, Evan Spruijt
wiley +1 more source
Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control
Advanced Science, EarlyView.Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui +12 more
wiley +1 more source