Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening [PDF]
eLifePhage-derived peptidoglycan hydrolases (i.e. lysins) are considered promising alternatives to conventional antibiotics due to their direct peptidoglycan degradation activity and low risk of resistance development.
Li Zhang +11 more
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Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics [PDF]
mBio, 2020 The Escherichia coli microcin C (McC) and related compounds are potent Trojan horse peptide-nucleotide antibiotics. The peptide part facilitates transport into sensitive cells.
Eldar Yagmurov +7 more
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Effect of nitrogen on activity of peptide hydrolases and protein content in caryopses and flag leaf of barley in ontogenesis [PDF]
E3S Web of Conferences, 2020 The aim of the research was to study the influence peculiarities of different levels of nitrogen nutrition on the activity of peptide hydrolases and protein content in ontogeny of barley plants.The paper discusses the content of total nitrogen, protein ...
Gamzaeva R S
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Novel M23 peptidases Pgp4, Pgp5, and Pgp6 contribute to helical cell shape in Campylobacter jejuni [PDF]
Frontiers in MicrobiologyThe helical morphology of Campylobacter jejuni is maintained by its peptidoglycan (PG) layer and influences its success as a pathogen. Periplasmic PG hydrolases that cleave the PG glycan backbone and peptide sidechains (such as carboxypeptidases and ...
Chang Sheng-Huei Lin +6 more
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The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives
Cells, 2022 N-terminal nucleophile (Ntn)-hydrolases catalyze the cleavage of amide bonds in a variety of macromolecules, including the peptide bond in proteins, the amide bond in N-linked protein glycosylation, and the amide bond linking a fatty acid to sphingosine ...
Arne Linhorst, Torben Lübke
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مجله دانشکده پزشکی اصفهان, 2021 Background: One of the causes of nosocomial infections is the dispersion of Aspergillus spores in the environment. The secretion of hydrolytic enzymes is considered as a virulence factor in Aspergillus species.
Faezeh Mohammadi +3 more
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Microbial proteases and their applications
Frontiers in Microbiology, 2023 Proteases (proteinases or peptidases) are a class of hydrolases that cleave peptide chains in proteins. Endopeptidases are a type of protease that hydrolyze the internal peptide bonds of proteins, forming shorter peptides; exopeptidases hydrolyze the ...
Peng Song +8 more
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Several genes encoding enzymes with the same activity are necessary for aerobic fungal degradation of cellulose in nature. [PDF]
PLoS ONE, 2014 The cellulose-degrading fungal enzymes are glycoside hydrolases of the GH families and lytic polysaccharide monooxygenases. The entanglement of glycoside hydrolase families and functions makes it difficult to predict the enzymatic activity of glycoside ...
Peter K Busk +3 more
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Biomolecules, 2020 Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD.
Fernando Valenzuela +6 more
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Inhibition of Staphylococcus aureus biofilm formation by gurmarin, a plant-derived cyclic peptide
Frontiers in Cellular and Infection Microbiology, 2022 Staphylococcus aureus (Sa) is an opportunistic pathogen capable of causing various infections ranging from superficial skin infections to life-threatening severe diseases including pneumonia and sepsis.
Adeline W. Chang +5 more
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