Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening [PDF]
eLifePhage-derived peptidoglycan hydrolases (i.e. lysins) are considered promising alternatives to conventional antibiotics due to their direct peptidoglycan degradation activity and low risk of resistance development.
Li Zhang +11 more
doaj +6 more sources
INHIBITION AND ACTIVATION OF BARLEY PEPTIDE HYDROLASES I. PEPTIDE HYDROLASE A [PDF]
Journal of the Institute of Brewing, 1971 Barley peptide hydrolase A acting on N-benzoyl-dl-arginine-p-nitroanilide as substrate is inhibited by the sulphydryl reagents N-ethyl maleimide and p-chloro-mercuriphenyl sulphonate. Oxidized glutathione, however, is non-inhibitory and several sulphydryl compounds are not stimulatory.
W. C. Burger +2 more
openalex +3 more sources
The Peptide Hydrolase System of the Leuconostoc
Journal of Food Protection, 1990 The intracellular peptide hydrolase activities of Leuconostoc species were determined using various aminopeptidase, dipeptidase, carboxypeptidase substrates, and casein. The activities were separated by disc gel electrophoresis. All strains had aminopeptidase activity as determined with amino acid ß-napthylamides and dipeptidase.
H. El‐Shafei, M. El‐Soda, N. Ezzat
openalex +4 more sources
Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics [PDF]
mBio, 2020 The Escherichia coli microcin C (McC) and related compounds are potent Trojan horse peptide-nucleotide antibiotics. The peptide part facilitates transport into sensitive cells.
Eldar Yagmurov +7 more
doaj +5 more sources
Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM [PDF]
eLifeOrchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of PG ...
Lina Antenucci +6 more
doaj +2 more sources
Specificity determinants of acylaminoacyl‐peptide hydrolase [PDF]
Protein Science, 1992 AbstractIn an attempt to explore how specific features of the substrate's primary structure may affect the activity of rabbit muscle acylaminoacyl‐peptide hydrolase (EC 3.4.19.1), a number of acetylated peptides containing specific amino acid replacements in specific positions were prepared and compared as substrates for the hydrolase.
Radha Krishna, Finn Wold
openalex +5 more sources
Peptide hydrolase activities of the mucosa of human small intestine [PDF]
Journal of Clinical Investigation, 1969 Few studies have been published on peptide hydrolase activities of human small intestine mucosa. We developed methods to screen tissue extracts for such enzymes and to quantitate hydrolase activities for dipeptides containing the aromatic amino acid L-phenylalanine.
William D. Heizer, Leonard Laster
openalex +4 more sources
Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide [PDF]
Molecular Neurodegeneration, 2009 Abstract Background The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and aggregates, and in senile plaques, fibrils.
Rina Yamin +4 more
openalex +7 more sources
Peptide hydrolases ofBrevibacterium linens [PDF]
FEMS Microbiology Letters, 1978 Helge Torgersen, Terje SÃ ̧rhaug
+5 more sources
Aspartic Peptide Hydrolases in Salmonella enterica Serovar Typhimurium [PDF]
Journal of Bacteriology, 2001 ABSTRACT Two well-characterized enzymes in Salmonella enterica serovar Typhimurium and Escherichia coli are able to hydrolyze N-terminal aspartyl (Asp) dipeptides: peptidase B, a broad-specificity aminopeptidase, and peptidase E, an Asp-specific dipeptidase.
Rachel A. Larsen +2 more
openalex +4 more sources