Design of Tetra-Peptide Ligands of Antibody Fc Regions Using In Silico Combinatorial Library Screening [PDF]
Pharmaceuticals, 2023 Peptides, or short chains of amino-acid residues, are becoming increasingly important as active ingredients of drugs and as crucial probes and/or tools in medical, biotechnological, and pharmaceutical research.
Marko Jukič +3 more
doaj +2 more sources
ALA‐A2 Is a Novel Anticancer Peptide Inspired by Alpha‐Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation [PDF]
Global Challenges, 2023 Anticancer peptides (ACPs) are rising as a new strategy for cancer therapy. However, traditional laboratory screening to find and identify novel ACPs from hundreds to thousands of peptides is costly and time consuming.
Tassanee Lerksuthirat +8 more
doaj +2 more sources
Analysis of Compositional Bias in a Commercial Phage Display Peptide Library by Next-Generation Sequencing [PDF]
Viruses, 2022 The principal presumption of phage display biopanning is that the naïve library contains an unbiased repertoire of peptides, and thus, the enriched variants derive from the affinity selection of an entirely random peptide pool.
Ane Beth Sloth +6 more
doaj +2 more sources
Synthesis, screening, and sequencing of cysteine-rich one-bead one-compound peptide libraries. [PDF]
, 2008 Cysteine-rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals. Due to the inherent difficulties created by cysteine, the power of one-bead one-compound (OBOC) libraries has
Greaves, John +3 more
core +4 more sources
Design of fully synthetic signal peptide library and its use for enhanced secretory production of recombinant proteins in Corynebacterium glutamicum [PDF]
Microbial Cell FactoriesBackground Corynebacterium glutamicum is an attractive host for secretory production of recombinant proteins, including high-value industrial enzymes and therapeutic proteins.
Eun Jung Jeon +3 more
doaj +2 more sources
Discovery of Surfactant-Like Peptides from a Phage-Displayed Peptide Library [PDF]
Viruses, 2020 Peptides with specific affinities for various materials have been identified in the past three decades and utilized in materials science and engineering. A peptide’s capability to specifically interact with materials is not naturally derived but screened
Toshiki Sawada +3 more
doaj +2 more sources
Biomathematical Description of Synthetic Peptide Libraries
PLOS ONE, 2015 Libraries of randomised peptides displayed on phages or viral particles are essential tools in a wide spectrum of applications. However, there is only limited understanding of a library's fundamental dynamics and the influences of encoding schemes and sizes on their quality.
Sieber, Timo +3 more
openaire +6 more sources
Algorithm-supported, mass and sequence diversity-oriented random peptide library design [PDF]
Journal of Cheminformatics, 2019 Random peptide libraries that cover large search spaces are often used for the discovery of new binders, even when the target is unknown. To ensure an accurate population representation, there is a tendency to use large libraries.
Daniela Kalafatovic +3 more
doaj +2 more sources
Genetically Encoded Libraries of Constrained Peptides [PDF]
ChemBioChem, 2019 AbstractMany therapeutic peptides can still be improved with respect to target specificity, target affinity, resistance to peptidases/proteases, physical stability, and capacity to pass through membranes required for oral delivery. Several modifications can improve the peptides’ properties, in particular those that impose (a) conformational constraint ...
Tjibbe Bosma +3 more
openaire +4 more sources
Bicyclic Peptide Library Screening for the Identification of Gαi Protein Modulators. [PDF]
J Med Chem, 2023 Pepanian A +9 more
europepmc +3 more sources