ALA‐A2 Is a Novel Anticancer Peptide Inspired by Alpha‐Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation [PDF]
Global Challenges, 2023 Anticancer peptides (ACPs) are rising as a new strategy for cancer therapy. However, traditional laboratory screening to find and identify novel ACPs from hundreds to thousands of peptides is costly and time consuming.
Tassanee Lerksuthirat +8 more
doaj +2 more sources
Analysis of Compositional Bias in a Commercial Phage Display Peptide Library by Next-Generation Sequencing [PDF]
Viruses, 2022 The principal presumption of phage display biopanning is that the naïve library contains an unbiased repertoire of peptides, and thus, the enriched variants derive from the affinity selection of an entirely random peptide pool.
Ane Beth Sloth +6 more
doaj +2 more sources
Bioactive Peptides from Libraries [PDF]
Chemistry & Biology, 2005 New ligands for a variety of biological targets can be selected from biological or synthetic combinatorial peptide libraries. The use of different libraries to select novel peptides with potential therapeutic applications is reviewed. The possible combination of molecular diversity provided by combinatorial libraries and a rational approach derived ...
Chiara Falciani +3 more
openalex +5 more sources
Design of fully synthetic signal peptide library and its use for enhanced secretory production of recombinant proteins in Corynebacterium glutamicum [PDF]
Microbial Cell FactoriesBackground Corynebacterium glutamicum is an attractive host for secretory production of recombinant proteins, including high-value industrial enzymes and therapeutic proteins.
Eun Jung Jeon +3 more
doaj +2 more sources
Discovery of Surfactant-Like Peptides from a Phage-Displayed Peptide Library [PDF]
Viruses, 2020 Peptides with specific affinities for various materials have been identified in the past three decades and utilized in materials science and engineering. A peptide’s capability to specifically interact with materials is not naturally derived but screened
Toshiki Sawada +3 more
doaj +2 more sources
Efficient In Vivo Selection of a Novel Tumor-Associated Peptide from a Phage Display Library [PDF]
Molecules, 2011 We developed a screening procedure to identify ligands from a phage display random peptide library that are selective for circulating bone marrow derived cells homing to angiogenic tumors.
Cam Patterson +7 more
doaj +2 more sources
Bicyclic Peptide Library Screening for the Identification of Gαi Protein Modulators. [PDF]
J Med Chem, 2023 Pepanian A +9 more
europepmc +3 more sources
Algorithm-supported, mass and sequence diversity-oriented random peptide library design [PDF]
Journal of Cheminformatics, 2019 Random peptide libraries that cover large search spaces are often used for the discovery of new binders, even when the target is unknown. To ensure an accurate population representation, there is a tendency to use large libraries.
Daniela Kalafatovic +3 more
doaj +2 more sources
An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors (Adv. Sci. 18/2025) [PDF]
Advanced scienceAndrew Brennan +3 more
europepmc +3 more sources
MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library. [PDF]
J Am Chem SocLi Z +13 more
europepmc +3 more sources