Results 101 to 110 of about 379,196 (358)

A molecular dynamics and circular dichroism study of a novel synthetic antimicrobial peptide [PDF]

, 2013
Antimicrobial peptides are a class of small, usually positively charged amphiphilic peptides that are used by the innate immune system to combat bacterial infection in multicellular eukaryotes. Antimicrobial peptides are known for their broad-spectrum antimicrobial activity and thus can be used as a basis for a development of new antibiotics against ...
arxiv   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

Communications Biology, 2023
Multivalent peptide library screens identify a tetravalent peptide that binds APP and A β via multivalent interactions and reduces A β in the brains of Alzheimer’s disease model mice.
Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Masataka Anzai, Seiko Ishihara, Nanako Nishioka, Hina Uchiyama, Juri Togashi, Saeka Nishihara, Kiyoshi Kawasaki, Takashi Saito, Takaomi C. Saido, Satoru Funamoto, Kiyotaka Nishikawa   +15 more
doaj   +1 more source

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. [PDF]

, 2011
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides.
Bauman, Jonathan N, Gelev, Vladimir M, Jacobson, Matthew P, Kalgutkar, Amit S, Leung, Siegfried SF, Linington, Roger G, Liras, Spiros, Lokey, R Scott, Mathiowetz, Alan M, McEwen, Cayla M, Price, David A, Rand, Arthur C, Renzelman, Chad M, Rezai, Taha, Turner, Rushia A, White, Tina R, Zhang, Yizhong   +16 more
core   +1 more source

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Blewett, Ann, Bugg, Tim, Clark, Tom, Levesque, Roger C., Lloyd, Adrian, Paradis-Bleau , Catherine, Sanschagrin, François   +6 more
core   +4 more sources

Rapid sampling of all-atom peptides using a library-based polymer-growth approach [PDF]

arXiv, 2009
We adapted existing polymer growth strategies for equilibrium sampling of peptides described by modern atomistic forcefields with implicit solvent. The main novel feature of our approach is the use of pre-calculated statistical libraries of molecular fragments.
arxiv  

Use of Peptide Libraries for Identification and Optimization of Novel Antimicrobial Peptides [PDF]

Current Topics in Medicinal Chemistry, 2016
The increasing rates of resistance among bacteria and to a lesser extent fungi have resulted in an urgent need to find new molecules that hold therapeutic promise against multidrug-resistant strains. Antimicrobial peptides have proven very effective against a variety of multidrug-resistant bacteria.
Ashby, Martin, Petkova, Asya, Gani, Jurnorain, Mikut, Ralf, Hilpert, Kai   +4 more
openaire   +4 more sources

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

Advanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung, Chu‐Chun Liang, Min‐Wei Huang, Tianle Chen, Joshua M. Little, Snehi Shrestha, Yi‐Chen Ethan Li, I‐Chi Lee, Po‐Yen Chen   +8 more
wiley   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Using NGS to Uncover the Corruption of a Peptide Phage Display Selection

Current Issues in Molecular Biology
Phage display has been widely used to identify peptides binding to a variety of biological targets. In the current work, we planned to select novel peptides targeting CD4 through screening of a commercial phage display library (New England Biolabs Ph.D ...
Danna Kamstrup Sell, Babak Bakhshinejad, Anders Wilgaard Sinkjaer, Ida Melissa Dawoodi, Mette Neiegaard Wiinholt, Ane Beth Sloth, Camilla Stavnsbjerg, Andreas Kjaer   +7 more
doaj   +1 more source