Results 181 to 190 of about 379,196 (358)

Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension [PDF]

arXiv
Peptides, short chains of amino acids, interact with target proteins, making them a unique class of protein-based therapeutics for treating human diseases. Recently, deep generative models have shown great promise in peptide generation. However, several challenges remain in designing effective peptide binders. First, not all residues contribute equally
arxiv  

M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1hi Neutrophils to Enhance Inflamed Bone Regeneration

Advanced Science, EarlyView.
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao, Yijia Yin, Fangyuan Shuai, Waishan Lam, Tao Zhou, Yaxin Xie, Xuesong He, Xianglong Han   +7 more
wiley   +1 more source

PDAUG: a Galaxy based toolset for peptide library analysis, visualization, and machine learning modeling. [PDF]

BMC Bioinformatics, 2022
Joshi J, Blankenberg D.
europepmc   +1 more source

Generation and screening of an oligonucleotide-encoded synthetic peptide library.

, 1993
Michael C. Needels, David G. Jones, Emily Tate, G L Heinkel, Lynn Kochersperger, William J. Dower, Ronald W. Barrett, Mark A. Gallop   +7 more
openalex   +1 more source

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

Advanced Science, EarlyView.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu, Amarnath Marudamuthu, Khadija Kakar, Hamida Hamida, Shruthi Thada, Rohan Gupta, Kiesha Wilson, Taylor Carter, Yin Zhong, Archana Saxena, Xiaoming Yang, Narendra Singh, Philip Brandon Busbee, Jie Li, Monica Garcia‐Buitrago, Prakash Nagarkatti, Mitzi Nagarkatti   +16 more
wiley   +1 more source

Hydroxamic Acid-Modified Peptide Library Provides Insights into the Molecular Basis for the Substrate Selectivity of HDAC Corepressor Complexes. [PDF]

ACS Chem Biol, 2022
Archibald LJ, Brown EA, Millard CJ, Watson PJ, Robertson NS, Wang S, Schwabe JWR, Jamieson AG.   +7 more
europepmc   +1 more source

HLA Class I Binding Motifs Derived from Random Peptide Libraries Differ at the COOH Terminus from Those of Eluted Peptides [PDF]

, 1997
Miles P. Davenport, Katherine J. Smith, Dan H. Barouch, Scott W. Reid, Wanda M. Bodnar, Anthony C. Willis, Donald F. Hunt, Adrian V. S. Hill   +7 more
openalex   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Rapid prediction of key residues for foldability by machine learning model enables the design of highly functional libraries with hyperstable constrained peptide scaffolds.

PLoS Computational Biology
Peptides are an emerging modality for developing therapeutics that can either agonize or antagonize cellular pathways associated with disease, yet peptides often suffer from poor chemical and physical stability, which limits their potential.
Fei Cai, Yuehua Wei, Daniel Kirchhofer, Andrew Chang, Yingnan Zhang   +4 more
doaj   +1 more source

Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor.

, 1992
Millard G. Cull, Jeff F. Miller, Peter J. Schatz   +2 more
openalex   +1 more source