Results 11 to 20 of about 433,652 (251)

In Silico Analysis of Neutralizing Antibody Epitopes on The Hepatitis C Virus Surface Glycoproteins [PDF]

Cell Journal, 2023
Objective: Despite of antiviral drugs and successful treatment, an effective vaccine against hepatitis C virus (HCV)infection is still required. Recently, bioinformatic methods same as prediction algorithms, have greatly contributed tothe use of peptides
Raziyeh Zareh-Khoshchehreh, Taravat Bamdad, Seyed Shahriar Arab, Mahdi Behdani, Mahmoud Biglar   +4 more
doaj   +1 more source

Adult Memory T Cell Responses to the Respiratory Syncytial Virus Fusion Protein During a Single RSV Season (2018–2019)

Frontiers in Immunology, 2022
Respiratory Syncytial Virus (RSV) is ubiquitous and re-infection with both subtypes (RSV/A and RSV/B) is common. The fusion (F) protein of RSV is antigenically conserved, induces neutralizing antibodies, and is a primary target of vaccine development ...
Brittani N. Blunck, Laura S. Angelo, David Henke, Vasanthi Avadhanula, Matthew Cusick, Laura Ferlic-Stark, Lynn Zechiedrich, Lynn Zechiedrich, Lynn Zechiedrich, Brian E. Gilbert, Pedro A. Piedra, Pedro A. Piedra   +11 more
doaj   +1 more source

The Screen of a Phage Display Library Identifies a Peptide That Binds to the Surface of Trypanosoma cruzi Trypomastigotes and Impairs Their Infection of Mammalian Cells

Frontiers in Microbiology, 2022
BackgroundChagas is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. On the order of seven million people are infected worldwide and current therapies are limited, highlighting the urgent need for new interventions.
Jéssica I. de Paula, Eduardo J. Lopes-Torres, Marcelo Jacobs-Lorena, Marcia Cristina Paes, Marcia Cristina Paes, Sung-Jae Cha   +5 more
doaj   +1 more source

Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA) [PDF]

, 2013
The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer phage
A Ghosh, AC Pawlyk, AM Quinn, CW Diehnelt, D Hessels, D Shen, DB Sodee, Duanwen Shen, E Basch, F Yi, Fei Xie, GA Lazar, H Liu, H Liu, H-S Lim, HD Agnew, IM Thompson, Irina U. Agoulnik, J Yu, JA Arter, JR Mesters, JR Newton, KA Noren, MI Davis, MI Milowsky, MJ Morris, MJ Morris, MJ Roobol, NH Bander, RK Nam, S Aggarwal, S Kim, S Minner, SE Lupold, SM Hillier, SR Banerjee, SR Banerjee, SR Banerjee, SR Banerjee, SS Chang, SZ Li, TJ Wigle, V Humblet, W. Barry Edwards, Y Chen, Y Chen, Y Chen, Z Xiao, ZY Zhu   +48 more
core   +18 more sources

Design of Tetra-Peptide Ligands of Antibody Fc Regions Using In Silico Combinatorial Library Screening

Pharmaceuticals, 2023
Peptides, or short chains of amino-acid residues, are becoming increasingly important as active ingredients of drugs and as crucial probes and/or tools in medical, biotechnological, and pharmaceutical research.
Marko Jukič, Sebastjan Kralj, Anja Kolarič, Urban Bren   +3 more
doaj   +1 more source

Screening technology of cyclic peptide library based on gene encoding

Medicine in Drug Discovery, 2022
As a powerful tool for the discovery of peptide compounds, high-throughput library screening technology can also perform multitarget screening with high chemical diversity as a condition, which accelerates the process of exploring high-affinity peptide ...
Yangqiang Chen, Chonggang Duan, Kai Chen, Shumeng Sun, Daizhou Zhang, Xiangjing Meng   +5 more
doaj   +1 more source

Large‐scale survey and database of high affinity ligands for peptide recognition modules

Molecular Systems Biology, 2020
Many proteins involved in signal transduction contain peptide recognition modules (PRMs) that recognize short linear motifs (SLiMs) within their interaction partners.
Joan Teyra, Abdellali Kelil, Shobhit Jain, Mohamed Helmy, Raghav Jajodia, Yogesh Hooda, Jun Gu, Akshay A D’Cruz, Sandra E Nicholson, Jinrong Min, Marius Sudol, Philip M Kim, Gary D Bader, Sachdev S Sidhu   +13 more
doaj   +1 more source

Phage-displayed peptide libraries [PDF]

Current Opinion in Biotechnology, 1998
Over the past year, significant advances have been achieved through the use of phage-displayed peptide libraries. A wide variety of bioactive molecules, including antibodies, receptors and enzymes, have selected high-affinity and/or highly-specific peptide ligands from a number of different types of peptide library.
M B, Zwick, J, Shen, J K, Scott
openaire   +2 more sources

Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume. [PDF]

, 2017
Peptide drugs have been difficult to translate into effective therapies due to their low in vivo stability. Here, we report a strategy to develop peptide-based therapeutic nanoparticles by screening a peptide library differing by single-site amino acid ...
Landry, Markita P, Li, Shang, Tu, Yaoquan, Wu, Junchen, Zou, Rongfeng   +4 more
core   +1 more source

Rapid microwave-assisted CNBr cleavage of bead-bound peptides [PDF]

, 2008
Large libraries of peptides, cyclic peptides, and other molecules are standard tools for the discovery of drugs, molecular probes, and affinity reagents.
Cha, Junhoe, Heath, James R., Lee, Su Seong, Lim, Jaehong, Tan, Sylvia   +4 more
core   +2 more sources