Results 241 to 250 of about 379,196 (358)

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

open access: yesAdvanced Science, EarlyView.
Polyglutamine (polyQ) tract expansion (≥ 36 amino acids) within the N‐terminal region of the Huntingtin protein (Httex1) causes Huntington's disease (HD), for which the underlying causes are not well‐understood. The authors performed computer simulations to understand the cause of HD at the molecular level.
Priyesh Mohanty   +2 more
wiley   +1 more source

Identification of a potent PCNA-p15-interaction inhibitor by autodisplay-based peptide library screening. [PDF]

open access: yesMicrob Biotechnol
Hardebeck S   +4 more
europepmc   +1 more source

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

open access: yesAdvanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang   +6 more
wiley   +1 more source

Combinatorial Peptide Libraries and Biometric Score Matrices Permit the Quantitative Analysis of Specific and Degenerate Interactions Between Clonotypic TCR and MHC Peptide Ligands [PDF]

open access: hybrid, 2001
Yingdong Zhao   +9 more
openalex   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

open access: yesAdvanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang   +13 more
wiley   +1 more source

Isolation of Peptide Ligands that Inhibit Glutamate Racemase Activity from a Random Phage Display Library

open access: hybrid, 2000
Woo-Chang Kim   +4 more
openalex   +1 more source

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