Results 21 to 30 of about 379,196 (358)

Pharmacophore Generation from a Drug-like Core Molecule Surrounded by a Library Peptide via the 10BASEd-T on Bacteriophage T7

open access: yesMolecules, 2014
We have achieved site-specific conjugation of several haloacetamide derivatives into designated cysteines on bacteriophage T7-displayed peptides, which are fused to T7 capsid protein gp10.
Yuuki Tokunaga   +5 more
doaj   +1 more source

Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design [PDF]

open access: yes, 2018
Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach.
A Stein   +41 more
core   +1 more source

Hydrogen sulfide intervention in focal cerebral ischemia/reperfusion injury in rats

open access: yesNeural Regeneration Research, 2015
The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion.
Xin-juan Li   +6 more
doaj   +1 more source

Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU [PDF]

open access: yes, 2002
Hsc66 and Hsc20 comprise a specialized chaperone system important for the assembly of iron-sulfur clusters in Escherchia coli. Only a single substrate, the Fe/S template protein IscU, has been identified for the Hsc66/Hsc20 system, but the mechanism by ...
Hoff, Kevin G.   +4 more
core   +1 more source

Molecular Screening Strategy to Identify a Non-invasive Delivery Mechanism for the Treatment of Middle Ear Disorders

open access: yesFrontiers in Medicine, 2020
Middle ear ailments include a broad range of pathological conditions. Otitis media is the leading middle ear disease of childhood, which incurs significant health care resources in developed countries and, in developing countries, causes significant ...
Arwa Kurabi   +7 more
doaj   +1 more source

Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. [PDF]

open access: yes, 2008
Lipid transfer proteins (LTPs) are the major allergens of Rosaceae fruits in the Mediterranean area. Pru p 3, the LTP and major allergen of peach, is a suitable model for studying food allergy and amino acid sequences related with its IgE-binding ...
Compes, Esther   +7 more
core   +2 more sources

Genetically Encoded Libraries of Nonstandard Peptides [PDF]

open access: yesJournal of Nucleic Acids, 2012
The presence of a nonproteinogenic moiety in a nonstandard peptide often improves the biological properties of the peptide. Non-standard peptide libraries are therefore used to obtain valuable molecules for biological, therapeutic, and diagnostic applications. Highly diverse non-standard peptide libraries can be generated by chemically or enzymatically
Hiroshi Murakami, Takashi Kawakami
openaire   +4 more sources

Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014

open access: yesNeural Regeneration Research, 2015
Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research.
Guang-yao Liu   +3 more
doaj   +1 more source

Synthesis, screening, and sequencing of cysteine-rich one-bead one-compound peptide libraries. [PDF]

open access: yes, 2008
Cysteine-rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals. Due to the inherent difficulties created by cysteine, the power of one-bead one-compound (OBOC) libraries has
Greaves, John   +3 more
core   +2 more sources

Nerve autografts and tissue-engineered materials for the repair of peripheral nerve injuries: a 5-year bibliometric analysis

open access: yesNeural Regeneration Research, 2015
With advances in biomedical methods, tissue-engineered materials have developed rapidly as an alternative to nerve autografts for the repair of peripheral nerve injuries. However, the materials selected for use in the repair of peripheral nerve injuries,
Yuan Gao   +6 more
doaj   +1 more source

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