Results 201 to 210 of about 38,957 (260)

Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity. [PDF]

RSC Chem Biol
Phan CS, Morinaka BI.
europepmc   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, EarlyView.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

High-Throughput Engineering and Modification of Non-Ribosomal Peptide Synthetases Based on Golden Gate Assembly. [PDF]

Angew Chem Int Ed Engl
Podolski A, Lindeboom TA, Präve L, Dehghan M, Minas HA, Kranz J, Schindler D, Bode HB.   +7 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Peptide halogenation biochemistry: interfacing pharmaceutical deliverables with chemical innovation. [PDF]

Med Chem Res
Agarwal V.
europepmc   +1 more source

Identification of an antimicrobial gene cluster in Serratia sp. [PDF]

, 2011
Cleto, S., Kluskens, Leon, Kolter, Roberto, Vieira, M. J., Vlamakis, Hera   +4 more
core  

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani, Fei Fang, Scott E. Counts, Liangliang Sun   +3 more
wiley   +1 more source

Genomic insights into biosynthetic gene cluster diversity and structural variability in marine bacteria. [PDF]

Sci Rep
Al-Siyabi N, Al-Ansari A, Abri MAA, Sivakumar N.   +3 more
europepmc   +1 more source

A Wagner-Meerwein-like rearrangement shapes the structures of the fischerazoles, cyanobacterial polychlorinated lipopeptides

Leao P, Figueiredo S, Abt K, Viehrig K, Jervis P, Martins T, Lacomba I, Castagnolo D.   +7 more
europepmc   +1 more source

Nonheme Fe Enzyme-Catalyzed Enantiodivergent Nitrogen Migration: Directed Evolution and Computational Study of Isopenicillin N Synthases for Biocatalytic Synthesis of Arylglycines. [PDF]

Angew Chem Int Ed Engl
Lin K, Zhao LP, Wang S, Liu H, Zhang Y, Mai BK, Liu P, Yang Y.   +7 more
europepmc   +1 more source